Stem Cells and Haemopoiesis

Dzierzak, Elaine

doi:10.1002/9781444323160.ch1

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…1 It involves the use of BMA needle that gains access to the marrow cavity where the aspirate is obtained, smeared, stained with Rowmanosky stains and viewed under light microscope where cytological details of the marrow elements will be examined. 1,2 There are various sites for BMA depending on the age of the patient and accessibility to a prominent bone. Posterior superior iliac spine is tagged as the most preferred site.…”

Section: Introductionmentioning

confidence: 99%

Bone marrow aspiration cytology in Abubakar Tafawa Balewa University Teaching Hospital, Bauchi State, Nigeria: Indications and diagnostic utility

Dachi

Mustapha

Yuguda³

et al. 2019

Ann Afr Med Res

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Bone Marrow Aspiration (BMA) cytology is an important diagnostic and monitoring tool where cytological details of the marrow elements are examined using light microscopy. Various hematological diseases are diagnosed and monitored by using BMA. This study aimed at reporting a 3-year BMA experience of Department of Hematology and Blood Transfusion of Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH) Bauchi. This was a retrospective study that involved the use of records of the bone marrow aspirates done from January 1st, 2016 to December 31st, 2018. The age, sex, indications for BMA, anatomical site and final bone marrow diagnosis were collated. The data was analyzed using SPSS Version 23.0 software. One hundred and three (103) bone marrow aspirations were performed during the period under review. Two third of the participants were males, with the median age of 40.0 years and a range of 5 months to 92 years. The commonest indication for BMA was recurrent anemia 45.6%, followed by splenomegaly, fever and lymphadenopathy with 11.7% each. While, the commonest diagnosis by BMA was megaloblastic anemia (28.2%). Mixed nutritional deficiency and Bone Marrow (BM) metastasis are the commoner BMA diagnoses with 12.6% each. Recurrent anemia is the commonest indication for BMA and nutritional anemias (megaloblastic and combined nutrients deficiency) are the commonest BMA diagnoses in Bauchi. Proper evaluation of patients by the clinicians before referral is recommended to ensure that only those that really need the procedure are subjected to it.

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Section: Introductionmentioning

confidence: 99%

Bone marrow aspiration cytology in Abubakar Tafawa Balewa University Teaching Hospital, Bauchi State, Nigeria: Indications and diagnostic utility

Dachi

Mustapha

Yuguda³

et al. 2019

Ann Afr Med Res

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“…Two main types of niches have been recognized: the endosteal (osteoblastic) and the endothelial (vascular) niche, localized within the trabecular regions of bones. 1 In these niches, HSCs interact with many different cell types, either directly or through chemokines, cytokines, growth factors, and enzymes. 2 Hematopoietic stem cell transplantation (HSCT) is based on stem cell homing, in a way that the infused HSCs migrate from blood to bone marrow.…”

Section: Introductionmentioning

confidence: 99%

Study of bone metabolism and angiogenesis in patients undergoing high‐dose chemotherapy/autologous hematopoietic stem cell transplantation

Boutsikas

Terpos

Παπαθεοδώρου

et al. 2017

European J of Haematology

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Bone resorption declined during HSCT (decrease in TRACP-5b [P < .001] and CTX [P = .006]). Bone formation declined as well (decrease in bALP and OC [P < .001 for both]). RANKL/OPG ratio, an indicator of osteoclastic activation, did not change significantly (P = .5). Ang1/Ang2 ratio, a vessel equilibrium marker, decreased significantly (P < .001) suggesting endothelial destabilization. The changes observed in the control group were similar except of bALP and RANKL/OPG ratio. Moreover, Ang1/Ang2 ratio on the day after HSC infusion strongly correlated with time to neutrophil and platelet engraftment (P < .001 for both). Conclusively, bone turnover and vessel destabilization represent important events during HSCT probably reflecting the effect of chemotherapy.

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Stem Cells and Haemopoiesis

Cited by 2 publications

References 59 publications

Bone marrow aspiration cytology in Abubakar Tafawa Balewa University Teaching Hospital, Bauchi State, Nigeria: Indications and diagnostic utility

Bone marrow aspiration cytology in Abubakar Tafawa Balewa University Teaching Hospital, Bauchi State, Nigeria: Indications and diagnostic utility

Study of bone metabolism and angiogenesis in patients undergoing high‐dose chemotherapy/autologous hematopoietic stem cell transplantation

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