Stem Cells and Nanomaterials

Hofmann, Marie‐Claude

doi:10.1007/978-94-017-8739-0_13

Cited by 22 publications

(11 citation statements)

References 176 publications

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“…The development of nanostructured materials has recently assumed great importance in cellular studies and regenerative medicine, since these materials may represent a smart solution to produce devices associated with significant human applications, manufactured at high production rates and volumes (for recent reviews, see e.g. Singh et al, ; Hopley et al , ; Hofmann, ; Fraczek‐Szczypta, ).…”

Section: Introductionmentioning

confidence: 99%

A peroxiredoxin-based proteinaceous scaffold for the growth and differentiation of neuronal cells and tumour stem cells in the absence of prodifferentiation agents

Cimini

Ardini

Gentile

et al. 2016

J Tissue Eng Regen Med

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The use of nanoscale materials in the design of scaffolds for CNS tissue is increasing, due to their ability to promote cell adhesion, to mimic an extracellular matrix microenvironment and to interact with neuronal membranes. In this framework, one of the major challenges when using undifferentiated neural cells is how to control the differentiation process. Here we report the characterization of a scaffold based on the self-assembled nanotubes of a mutant of the protein peroxiredoxin (from Schistosoma mansoni or Bos taurus), which allows the growth and differentiation of a model neuronal cell line (SHSY5Y). The results obtained demonstrate that SHSY5Y cells grow without any sign of toxicity and develop a neuronal phenotype, as shown by the expression of neuronal differentiation markers, without the use of any differentiation supplement, even in the presence of serum. The prodifferentiation effect is demonstrated to be dependent on the formation of the protein nanotube, since a wild-type (WT) form of the peroxiredoxin from Schistosoma mansoni does not induce any differentiation. The protein scaffold was also able to induce the spread of glioblastoma cancer stem cells growing in neurospheres and allowing the acquisition of a neuron-like morphology, as well as of immature rat cortical neurons. This protein used here as coating agent may be suggested for the development of scaffolds for tissue regeneration or anti-tumour devices. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

A peroxiredoxin-based proteinaceous scaffold for the growth and differentiation of neuronal cells and tumour stem cells in the absence of prodifferentiation agents

Cimini

Ardini

Gentile

et al. 2016

J Tissue Eng Regen Med

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“…Metal nanoparticles have been commonly used in the labeling and tracking of stem cells [ 57 ] and to trigger stem cell differentiation [ 57 , 58 ]. Magnetic nanoparticles are currently being explored as a means for manipulating stem cell behavior and for 3D building of complex tissues [ 59 ].…”

Section: Composite Hydrogelsmentioning

confidence: 99%

Creating Structured Hydrogel Microenvironments for Regulating Stem Cell Differentiation

Mills

Luo

Elumalai

et al. 2020

Gels

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The development of distinct biomimetic microenvironments for regulating stem cell behavior and bioengineering human tissues and disease models requires a solid understanding of cell–substrate interactions, adhesion, and its role in directing cell behavior, and other physico-chemical cues that drive cell behavior. In the past decade, innovative developments in chemistry, materials science, microfabrication, and associated technologies have given us the ability to manipulate the stem cell microenvironment with greater precision and, further, to monitor effector impacts on stem cells, both spatially and temporally. The influence of biomaterials and the 3D microenvironment’s physical and biochemical properties on mesenchymal stem cell proliferation, differentiation, and matrix production are the focus of this review chapter. Mechanisms and materials, principally hydrogel and hydrogel composites for bone and cartilage repair that create “cell-supportive” and “instructive” biomaterials, are emphasized. We begin by providing an overview of stem cells, their unique properties, and their challenges in regenerative medicine. An overview of current fabrication strategies for creating instructive substrates is then reviewed with a focused discussion of selected fabrication methods with an emphasis on bioprinting as a critical tool in creating novel stem cell-based biomaterials. We conclude with a critical assessment of the current state of the field and offer our view on the promises and potential pitfalls of the approaches discussed.

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“…Nanotechnology can be very helpful since nanomaterials can be used as scaffolds to improve the engraftment of stem cells onto the damaged tissue. In addition, the use of nanoparticles (NPs) for gene/drug delivery can complement the therapeutic benefits of transplanted stem cells, and allow the tracking of the cells inside the body [90].…”

Section: Use Of Placenta Mesenchymal Stem/stromal Cells (Pmsc) and Namentioning

confidence: 99%

Human Placenta-Derived Mesenchymal Stromal Cells: A Review from Basic Research to Clinical Applications

Torre¹,

Pérez-Lorenzo²,

Flores³

2019

Stromal Cells - Structure, Function, and Therapeutic Implications

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Placenta-derived mesenchymal stem/stromal cells (PMSC) present several aspects that make them more attractive as cellular therapy than their counterparts from other tissues, such as MSC from bone marrow or adipose tissue in regenerative medicine. Placenta-derived MSC have been used to treat a variety of disorders, such as, cancer, liver and cardiac diseases, ulcers, bone repair, and neurological diseases. Placenta-derived MSC are relatively new types of MSC with specific immunomodulatory properties and whose mechanisms are still unknown. Placenta-derived MSC secrete some soluble factors that seem to be responsible for their therapeutic effects, i.e., they have paracrine effects. On the other hand, Placentaderived MSC can also serve as cellular vehicles and/or delivery systems for medications due to their migration capacity and their tropism for injury sites. Nanotechnology is an important field, which has undergone rapid development in recent years for the treatment of injured organs. Due to the special characteristics of placenta-derived MSC, the combination of these cells with nanotechnology will be a significant and highly promising field that will provide significant contributions in the regenerative medicine field in the near future.

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Stem Cells and Nanomaterials

Cited by 22 publications

References 176 publications

A peroxiredoxin-based proteinaceous scaffold for the growth and differentiation of neuronal cells and tumour stem cells in the absence of prodifferentiation agents

A peroxiredoxin-based proteinaceous scaffold for the growth and differentiation of neuronal cells and tumour stem cells in the absence of prodifferentiation agents

Creating Structured Hydrogel Microenvironments for Regulating Stem Cell Differentiation

Human Placenta-Derived Mesenchymal Stromal Cells: A Review from Basic Research to Clinical Applications

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