Stem cells and neonatal brain injury

Ikeda, Tomoaki

doi:10.1007/s00441-007-0546-8

Cited by 15 publications

(9 citation statements)

References 48 publications

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“…Considering that cell migration plays an important role in the injury-induced neurogenesis and tissue regeneration [ 13 , 14 ] . For example, progenitor cells from periventricular region proliferate and migrate into the hippocampus to regenerate new neurones after ischemia and reduce neurological deficits in vivo .…”

Section: Resultsmentioning

confidence: 99%

MiR-375 attenuates injury of cerebral ischemia/reperfusion via targetting Ctgf

Kou

Liang

et al. 2017

Bioscience Reports

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Ischemic stroke is the leading cause of disability and deaths worldwide. MiRNAs have been shown to play an important role in development and pathogenesis of the nervous system. However, the precise function and mechanism of miRNAs are not fully understood in the brain injury induced by ischemia/reperfusion (I/R). Herein, our study showed that miR-375 expression was significantly down-regulated in the rat I/R brain. With the in vivo and in vitro I/R stroke models, we found that miR-375 mimic provides significant protection from injury to cerebral I/R, which is reflected by reduced infarct volumes and cell apoptosis, and increased proliferation and migration of PC12 cells. Mechanistically, our findings showed that miR-375 binds to 3′-UTR region of Ctgf mRNA, subsequently leading to the decreased expression of Ctgf in the I/R brain. Furthermore, we showed that miR-375/Ctgf-mediated protective effects are associated with p21/PI3K/Akt signaling pathways. Our findings thus provide a new insight into the mechanism of cerebral I/R injury and pave a potential new way for the therapy of cerebral I/R injury.

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Section: Resultsmentioning

confidence: 99%

MiR-375 attenuates injury of cerebral ischemia/reperfusion via targetting Ctgf

Kou

Liang

et al. 2017

Bioscience Reports

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“…Accumulating evidence has indicated that periostin is a neurite outgrowth-promoting factor. Periostin promotes the proliferation and differentiation of neural stem cells in the brain after ischaemic or haemorrhagic injury 19 , which may rescue neuronal loss and restore brain function 20 . An injection of periostin into the lateral ventricles of hypoxic-ischaemic rats was recently shown to significantly improve spatial learning and memory, indicating that periostin may reverse cognitive deficits after IS 19 .…”

Section: Discussionmentioning

confidence: 99%

Longitudinal evaluation of serum periostin levels in patients after large-artery atherosclerotic stroke: A prospective observational study

Bao

Shen

et al. 2018

Sci Rep

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Increasing evidence supports the involvement of periostin in the pathophysiological processes of stroke and atherosclerosis. The aim of this study was to assess circulating periostin levels at different times after large-artery atherosclerotic (LAA) stroke and their association with stroke. Serum periostin levels were measured using enzyme-linked immunosorbent assay on day 1 in 162 patients with LAA stroke and in 108 age- and sex-matched controls, on day 6 after stroke in 134 patients, and during the 4th week after stroke in 46 of the 162 patients. Stroke severity was determined using the National Institutes of Health Stroke Scale (NIHSS), and the stroke volume was measured. Outcome at 3 months was measured using the modified Rankin Scale (mRS). Our results indicated that periostin levels increased significantly on day 6 after stroke, and this increasing trend persisted for at least 4 weeks after the event. In addition, the increase in periostin levels was positively correlated with the NIHSS scores and stroke volume, but not with the mRS scores after adjusting for the NIHSS scores. In conclusion, these findings suggest that the increase in serum periostin levels observed after stroke may be associated with the stroke severity in patients with LAA stroke.

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“…An article by Ikeda (2007) describes recent experimental results, including data from his laboratory, regarding neuronal stem cells and neonatal brain damage. The review focuses on hypoxic-ischemic brain injury as a model of neonatal brain injury, which is considered as one of the optimal candidates for regenerative therapy.…”

Section: Neural Stem Cellsmentioning

confidence: 97%