Stem cells and progenitor cell lineages as targets for neoplastic transformation in the central nervous system

Petritsch, Claudia

doi:10.1016/b978-0-443-06967-3.00002-8

Cited by 1 publication

(1 citation statement)

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“…1 In the early stages of the central nervous system development, the cerebellar progenitor cells arise from two major germinal zones, and generate distinct populations of the neural cells that compose the cerebellum: the peri-ventricular germinal matrix, in the cerebellar plate, over the fourth ventricle, and the external granular layer. 5,8 As this tumor has a neuroectodermal origin, 6,9,10 its extra-axial location may be associated to remnants of the neural crest stem cells, which persisted specifically in the cerebellopontine angle, from where the medulloblastoma arose. The tumor may extend through the fourth ventricle into the aqueduct of Sylvius or into the cisterna magna, through the foramen of Magendie.…”

Section: Discussionmentioning

confidence: 99%

Extra-Axial Cerebello-Pontine Angle Medulloblastoma

et al. 2016

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Medulloblastoma is the most common central nervous system tumor in children. Extra-axial medulloblastomas, especially tumors with no connection to the brain stem or cerebellum are extremely rare. We report a case of a 3-year-old patient, who presented with a history of subacute headache and vomiting. After performing a head computed tomography scan, a mass was detected in the left cerebello-pontine angle, along with concomitant hydrocephalus. The treatment was total resection of the tumor. Despite the fact that extra-axial medulloblastomas are extremely rare, this differential diagnosis should be included in the management of pediatric patients who present with posterior fossa tumors.

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Section: Discussionmentioning

confidence: 99%