Stem cells and regenerative medicine in urology, part 2: Urothelium, urinary bladder, urethra and prostate

Pastor-Navarro, T.; Beamud-Cortés, M.; Fornas-Buil, E.; Moratalla-Charcos, L.M.; Osca-García, J.M.; Gil-Salom, Manuel

doi:10.1016/s2173-5786(10)70146-3

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“…Research on potential use of stem cells in regenerative medicine is peaking, but urology is somewhat behind other specialties when it comes to stem cell research 142 . Only a few studies exploring the potential value of stem cell therapy in urology have been performed and they included studies of bladder dysfunction, erectile dysfunction, stress urinary incontinence, and prostate and bladder cancer.…”

Section: What Kind Of Ham Would Make the Best Scaffold?mentioning

confidence: 99%

Human Amniotic Membrane and Amniotic Membrane–Derived Cells

Ramuta

Kreft

2018

Cell Transplant

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Human amniotic membrane (hAM) is the innermost layer of fetal membranes, which surrounds the developing fetus and forms the amniotic cavity. hAM and hAM-derived cells possess many properties that make them suitable for use in regenerative medicine, such as low immunogenicity, promotion of epithelization, anti-inflammatory properties, angiogenic and antiangiogenic properties, antifibrotic properties, antimicrobial properties, and anticancer properties. Many pathological conditions of the urinary tract lead to organ damage or complete loss of function. Consequently, the reconstruction or replacement of damaged organs is needed, which makes searching for new approaches in regenerative and reconstructive urology a necessity. The use of hAM for treating defects in kidneys, ureters, urinary bladder, and urethra was tested in vitro in cell cultures and in vivo in mice, rats, rabbits, cats, dogs, and also in humans. These studies confirmed the advantages and the potential of hAM for use in regenerative and reconstructive urology as stated above. However, they also pointed out a few concerns we have to take into consideration. These are (1) the lack of a standardized protocol in hAM preparation and storage, (2) the heterogeneity of hAM, and especially (3) low mechanical strength of hAM. Before any wider use of hAM for treating urological defects, the protocols for preparation and storage will need to be standardized, followed by more studies on larger animals and clinical trials, which will altogether extensively assess the potential of hAM use in urological patients.

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Section: What Kind Of Ham Would Make the Best Scaffold?mentioning

confidence: 99%