Stem Cells and the Ocular Lens: Implications for Cataract Research and Therapy

Murphy, Patricia A.; O’Connor, Michael D.

doi:10.1007/978-1-4939-0787-8_9

Cited by 2 publications

(2 citation statements)

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“…The crystalline lens, posterior to the iris and anterior to the vitreous body and retina, has the ability to change the focus between near and far objects [4,5]. Therefore, any change in the refractive index can potentially be the origin of opacity or clouding.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the nuclear cataract formation process is slow, gradual, and immutable [5,10]. The refractive index that makes the lens transparent is achieved by the expression and accumulation of crystallin proteins such as α−, β-, and γcrystallins [4]. Hence, any alteration of the structure or composition of the lens can lead to opacity or clouding.…”

Section: Introductionmentioning

confidence: 99%

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Simulation and analysis of light scattering by multilamellar bodies present in the human eye

Méndez-Aguilar

Kelly-Pérez

Berriel‐Valdos

et al. 2017

Biomed. Opt. Express

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A modified computational model of the human eye was used to obtain and compare different probability density functions, radial profiles of light pattern distributions, and images of the point spread function formed in the human retina under the presence of different kinds of particles inside crystalline lenses suffering from cataracts. Specifically, this work uses simple particles without shells and multilamellar bodies (MLBs) with shells. The emergence of such particles alters the formation of images on the retina. Moreover, the MLBs change over time, which affects properties such as the refractive index of their shell. Hence, this work not only simulates the presence of such particles but also evaluates the incidence of particle parameters such as particle diameter, particle thickness, and shell refractive index, which are set based on reported experimental values. In addition, two wavelengths (400 nm and 700 nm) are used for light passing through the different layers of the computational model. The effects of these parameters on light scattering are analyzed using the simulation results. Further, in these results, the effects of light scattering on image formation can be seen when single particles, early-stage MLBs, or mature MLBs are incorporated in the model. Finally, it is found that particle diameter has the greatest impact on image formation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%