Stem Cells for Diabetes Complications: A Future Potential Cure

Khamaisi, Mogher; Balanson, Sarit

doi:10.5041/rmmj.10283

Cited by 14 publications

(12 citation statements)

References 32 publications

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“…On the contrary, in the islet transplantation technique if the transplant works properly, the results will be very promising; thus, glycemic control is done by the body itself, and the amount of insulin needed is given to the body with respect to the amount of body glucose in the body; and homeostasis is done normally. Stem cell therapy for DM, which is in fact an attempt to eliminate insulin injections, leads to complications such as infectious diseases and cancer (8)(9)(10). Side-effects can occur at any time during, immediately, or several days or months after stem cell transplantation.…”

Section: Introductionmentioning

confidence: 99%

Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits

Rahim¹,

Arjmand²,

Shirbandi³

et al. 2018

Non-coding RNA Investig

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Background: There is a general agreement that to ensure promising results of stem cell therapy in patients with diabetes, one must first understand its risks and benefits; thus, if the risk is sufficiently low along with many benefits, it can lead to developing a novel therapeutic approach based on sound science.Methods: A systematic review and meta-analysis was performed using all available clinical trials to determine the benefits and risks associated with stem cell therapy in patients with diabetes (both T1DM and T2DM). An extensive search was conducted across several databases using all MeSH words regarding stem cell therapy and diabetes.Results: In T2DM, a large body of research has shown that stem cell therapy has improved the insulin daily requirement and glycosylated hemoglobin (HbA1C) levels, and also has a positive effect on these variables, but has a negative impact on c-peptide. Hence, in T1DM, stem cell therapy improves c-peptide and HbA1C levels and has a positive effect on these variables, but has a negative impact on insulin daily requirement.Conclusions: A total of 639 cells have the ability to self-renew and differentiate into a variety of cells, including blood, heart, nervous and cartilage cells. Paradoxically, it has been stated that these cells also have the potential to form cancer cells. These possible risks warrant caution by both medical specialists and patients while proceeding with the treatment; thus, it is critically crucial to conduct further research on stem cell therapy but with first considering their risk and benefits.

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Section: Introductionmentioning

confidence: 99%

Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits

Rahim¹,

Arjmand²,

Shirbandi³

et al. 2018

Non-coding RNA Investig

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“…Metabolic disturbances associated with diabetes lead to a number of complications ranging from cardiovascular and cerebrovascular disease to neuropathy, retinopathy, nephropathy, and the poor healing of wounds[42]. The only curative therapy available is pancreatic islet cell replacement, for which suitable donors are rare and which requires immunosuppressant therapy to reduce rejection.…”

Section: Endodermal Differentiation Of T-scsmentioning

confidence: 99%

Tonsil-derived stem cells as a new source of adult stem cells

Cho¹,

Lee²,

Jeong³

et al. 2019

WJSC

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Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors ( i.e ., under 10 years old). As such, T-SCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal ( e.g ., hepatocytes and parathyroid-like cells), and even ectodermal cells ( e.g ., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.

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“…Diabetes not only disrupts the blood glucose regulations but also alters the metabolism in long run if poorly managed. As a result, micro- and macrovascular complications occur [ 98 – 100 ]. The microvascular complications arise due to impairment in small blood vessels under chronic hyperglycemic milieu.…”

Section: Stem Cells In Diabetic Complicationsmentioning

confidence: 99%

“…Regeneration and differentiation capability of stem cells make it possible to explore their therapeutic potential to treat and control diabetic complications. Specifically, the multipotent stem cells such as MSCs/HSCs, progenitor stem cells, tissue-specific stem cells, and pluripotent stem cells (ESCs and iPSCs) are considered to counter the diabetes-associated disorders [ 98 , 100 ]. Therefore, the selection of the suitable source of stem cells is critical to ensure the differentiation of stem cells into both endothelial and perivascular cells to repair diabetic complications [ 105 ].…”

Section: Stem Cells In Diabetic Complicationsmentioning

confidence: 99%

Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications

Peng

Dubey

Mishra³

et al. 2018

Journal of Diabetes Research

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High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.

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Stem Cells for Diabetes Complications: A Future Potential Cure

Cited by 14 publications

References 32 publications

Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits

Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits

Tonsil-derived stem cells as a new source of adult stem cells

Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications

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