Pancreatic Cancer - Insights Into Molecular Mechanisms and Novel Approaches to Early Detection and Treatment 2014
DOI: 10.5772/57530
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Stem Cells in Pancreatic Cancer

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Cited by 2 publications
(3 citation statements)
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References 167 publications
(174 reference statements)
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“…CSCs have been identified in a spectrum of cancer types and they are now considered as the culprit of drug resistance, distance metastasis, and disease recurrence . Pancreatic cancer also received much attention due to its extremely poor prognosis and difficulty in controlling the disease.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…CSCs have been identified in a spectrum of cancer types and they are now considered as the culprit of drug resistance, distance metastasis, and disease recurrence . Pancreatic cancer also received much attention due to its extremely poor prognosis and difficulty in controlling the disease.…”
Section: Discussionmentioning
confidence: 99%
“…CSCs contain the ability of self‐renewal and have the potential to regenerate into all types of differentiated cells within tumor mass and contribute to drive continued tumorigenesis. Thus, the failure to eliminate CSCs is considered to be one of the underlying causes of treatment failure . Thus, the identification of agents that can target and eliminate CSCs may provide the much needed arsenal for combating clinically challenges encountered in patients with pancreatic cancer.…”
Section: Introductionmentioning
confidence: 99%
“…Various elements regulate the properties and conduct of pancreatic CSCs, for example, nestin can balance attack or metastasis of pancreatic CSCs, Oct-4 and Nanog can direct pancreatic CSC's conduct and metastasis to different organs, DCLK1 can segregate between normal and tumoral stem cells and Sox2 controls cell proliferation and differentiation [31]. Furthermore, c-Kit and Kras likewise tweak the movement of pancreatic adenocarcinoma [32].…”
Section: Accepted Manuscriptmentioning
confidence: 99%