Stem cells, niches and scaffolds: Applications to burns and wound care

Watt, Suzanne M.; Pleat, Jonathon

doi:10.1016/j.addr.2017.10.012

Cited by 54 publications

(36 citation statements)

References 349 publications

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“…Many factors affect the migration, proliferation, and differentiation of epidermal SCs. Extrinsic factors mainly include regulators that form the niche of SCs, consisting of adjacent cells, matrix architecture, signaling molecules, physical forces, oxygen tension, and other environmental factors [27]. Proinflammatory cytokines, including TNF-α, IL-1, IL-6, and IL-17, are intrinsic factors, and they promote the migration, proliferation, and differentiation via both autocrine and paracrine ways.…”

Section: The Origin Differentiation and Regulation Of Epidermal Stementioning

confidence: 99%

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

et al. 2020

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The skin, which serves as the first barrier of the human body, is particularly susceptible to exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are commonly observed in clinics. Healing of skin wounds is a complex process, consisting of infiltration of inflammatory cells, cellular proliferation, and tissue remodeling phases, which restore the integrity and functions of the skin. Epithelialization is involved in wound healing through re-establishing an intact keratinocyte layer. Epidermal stem cells are indispensable for epithelialization, and they are regulated by multiple proinflammatory cytokines or growth factors. In this review, we summarize recent advances in the effect of these cytokines on migration, proliferation, and differentiation processes of epidermal stem cells. We also introduce promising therapeutic strategies targeting epidermal stem cells or related proinflammatory cytokines for patients with skin wounds.

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Section: The Origin Differentiation and Regulation Of Epidermal Stementioning

confidence: 99%

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

et al. 2020

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“…200 Other covers are improving in quality and may become methods of permanent skin replacement, potentially avoiding temporary skin replacement and grafting altogether. 201,202 Examples include allogeneic engineered skin substitutes (ESSs), autologous composite cultured skin (CCS) and threedimensional (3D) bioprinting.…”

Section: Surgical Managementmentioning

confidence: 99%

A Critical Update of the Assessment and Acute Management of Patients with Severe Burns

Lang

Zhao²,

Kim

et al. 2019

Advances in Wound Care

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Burns are debilitating, life threatening, and difficult to assess and manage. Recent advances in assessment and management have occurred since a comprehensive review of the care of patients with severe burns was last published, which may influence research and clinical practice. Recent Advances: Recent advances have occurred in the understanding of burn pathophysiology, which has led to the identification of potential biomarkers of burn severity, such as protein C. There is new evidence about the potential superiority of natural colloids over crystalloids during fluid resuscitation, and new evidence about components of initial and perioperative management, including an improved understanding of pain following burns. Critical Issues: The limitations of the clinical examination highlight the need for imaging and biomarkers to assist in estimations of burn severity. Fluid resuscitation reduces mortality, although there is conjecture over the ideal method. The subsequent perioperative period is associated with significant morbidity and the evidence for preventing and treating pain, infection, and fluid overload while maximizing wound healing potential is described. Future Directions: Promising developments are ongoing in imaging technology, histopathology, biomarkers, and wound healing adjuncts such as hyperbaric oxygen therapy, topical negative pressure therapy, stem cell treatments, and skin substitutes. The greatest benefit from further research on management of patients with burns would most likely be derived from the elucidation of optimal fluid resuscitation protocols, pain management protocols, and surgical techniques from randomized controlled trials.

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“…to delay in tissue regeneration. Chronic wounds have lower levels of growth factors and chemokine production, a slower vessel formation, fibroblast proliferation, the interrupted inflammation in a tissue reparation process [1]. If traditional conservative and surgical therapies do not aid at curing chronic wounds, the latter accepted as non-healing.…”

Section: Reviewsmentioning

confidence: 99%

Regenerative therapy for the nonhealing cutaneous wounds

et al. 2018

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Regenerative medicine therapy is inspired by current research advances in cellular biology, genetic engineering, synthetic biology, material sciences and so far contributes to the traditional therapy, making resistant diseases curable. Nowadays, chronic wound healing is possible due to cell-based regenerative technologies and recent non-cell therapeutic approaches. Here we review clinical applications of human stem cells, as well as cellular and tissue products as alternatives to the traditional therapy of non-healing wounds. The cell-based technologies for tissue regeneration and bioengineering utilize stem cells that are either injected into bloodstream or positioned directly into the target area. Cell-free regeneration technologies require either stem cell products, i.e., secretomes or their separate components, extracellular membrane vesicles, or tissue products. The stem cell therapies are designed to replace critically absent components of wounded or degenerative tissue. The stem cell secretome can promote the repair of damaged tissues independently of parent cells. Extracellular membrane vesicles mimic and recapitulate the mechanisms of stem cells in tissue regeneration and therefore might be promising for chronic wound and severe burns healing. The tissue products traditionally remain efficient wound healing remedies along with emerging advanced technologies. K e y w o r d s: wound healing, cell and cell-free technologies, stem cells, secretomes, extracellular membrane vesicles, tissue products

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Stem cells, niches and scaffolds: Applications to burns and wound care

Cited by 54 publications

References 349 publications

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

A Critical Update of the Assessment and Acute Management of Patients with Severe Burns

Regenerative therapy for the nonhealing cutaneous wounds

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