Stem Cells Therapy in Diabetes Mellitus

Xi, Yang; Bu, Shizhong

doi:10.4172/2157-7633.1000199

Cited by 8 publications

(19 citation statements)

References 91 publications

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“…Although occurring in low frequency, these results suggest that BMSCs have the ability to differentiate into β-cells. 44 Xi and Bu, 2 found that autologous MSCs transplantation in a rat model of (T2D) resulted in enhanced insulin secretion, increased islet numbers in pancreas and ameliorated insulin sensitivity, suggesting functional effects of MSCs on insulin target tissues which lead to the reduction of blood glucose level as shown in the present work.…”

Section: Discussionsupporting

confidence: 74%

“…According to Kim et al., 23 the majority of diabetes loss pathology can be traced to the decrease and/or dysfunction of beta-cells. 2 Different reasons have been put forward for this decrease, such as oxidative stress, endoplasmic reticulum stress, and amyloid formation toxicity. 24 It must also be noted that, as diabetes cases progress, β-cell mass levels decrease and glucose levels increase.…”

Section: Discussionmentioning

confidence: 99%

“…Both types of diabetes, 1 and 2, are serious and common health risks with several long-term negative effects, which can thus lead to ever-growing expense. 2 …”

Section: Introductionmentioning

confidence: 99%

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Mesenchymal stem cells: a future experimental exploration for recession of diabetic nephropathy

et al. 2016

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Background: The progresses made in stem cell therapy offer an innovative approach and exhibit great potential for the repair of damaged organs and tissues. This study was conducted with a view to find the mechanisms responsible for the effectiveness of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the suppression of diabetes and experimentally-induced diabetic nephropathy.Methods: To realize this objective, diabetic and diabetic nephropathy subject groups that underwent MSC treatment were studied through numerous biochemistry and molecular genetics analyses.Results: The findings show that, relative to the control groups, the rats in the diabetic and diabetic nephropathy groups treated with stem cells infused with BM-MSCs showed a significant reversal in the levels of their insulin, glucose, heme-oxygenase-1 (HO-1) serum, and advanced glycation end product (AGEP). Moreover, BM-MSC therapy was also found to have a definite positive effect on the kidney functions. In addition, it also corresponded with a significant decrease in the availability of certain growth factors, namely the fibroblast growth factor (FGF), the platelet-derived growth factor (PDGF), and the transforming growth factor-β (TGF-β). BM-MSC treatment also improved the levels of expression of monocyte chemoatractant-1 (MCP-1) and interleukin-8 (IL-8) genes within kidney tissues. Lastly, the treatment recovered the organizational structure of the kidney and pancreas, a result demonstrated by a histopathological analysis. These results greatly coincide with those obtained through the biochemistry and molecular genetics analyses.Conclusion: Treatment using BM-MSCs is determined to be definitely effective in cases of diabetes and diabetic nephropathy.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Mesenchymal stem cells: a future experimental exploration for recession of diabetic nephropathy

et al. 2016

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“…Sel punca mesensimal tidak berdiferensiasi secara in vivo menjadi jaringan kerangka, melainkan berfungsi sebagai parakrin, yaitu pusat sekretori di lokasi cidera. Sel punca ini mampu memproduksi protein dan sitokin untuk perbaikan jaringan, zat imunomodulator yang dapat menekan inflamasi karena luka maupun karena penolakan transplantasi jaringan oleh tubuh (Azapira et al, 2015;Kay et al, 2017), serta sifat proangiogenik yang berpotensi untuk terapi (Xi dan Bu, 2014).…”

Section: Mesenchymal Stem Cells (Mscs)unclassified

“…Sel punca mesensimal (SPM) merupakan salah satu jenis sel punca yang terdapat pada sumsum tulang, jaringan adiposa, darah tali pusat, dan Wharton jelly dari tali pusat (Azarpira et al, 2015). SPM mampu memproduksi protein dan sitokin untuk perbaikan jaringan, zat imunomodulator yang dapat menekan inflamasi karena luka maupun karena penolakan oleh tubuh (Azarpira et al, 2015;Lozito et al, 2009), serta memiliki sifat pro-angiogenik (Xi & Bu, 2014).…”

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Aplikasi Media Terkondisi Sel Punca Mesensimal dalam Terapi Penyakit Degeneratif dan Penyembuhan Luka

Widhiastuti¹

2020

Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati

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Penyakit degeneratif seperti stroke, jantung, hipertensi, dan diabetes merupakan penyakit yang banyak dialami seseorang seiring dengan bertambahnya usia. Terapi dengan obat-obatan maupun dengan operasi telah banyak digunakan Namun pada beberapa kasus, hasilnya belum maksimal. Dengan meningkatnya ilmu pengetahuan dan teknologi, sel punca juga dikembangkan sebagai terapi regeneratif, tidak hanya untuk pengobatan penyakit degeneratif namun juga untuk penyembuhan luka akibat trauma fisik maupun penyakit yang lain. Salah satu macam sel punca yang banyak digunakan adalah sel punca mesensimal (SPM). Meskipun sel punca memiliki potensi untuk dikembangkan sebagai terapi penyakit degeneratif dan penyembuhan luka, namun proses diferensiasinya dalam tubuh belum terkontrol dengan maksimal, sehingga banyak peneliti mengembangkan penggunaan media terkondisi sel punca mesensimal (MT-SPM) sebagai terapi alternatif. MT-SPM yang merupakan medium cair tempat tumbuh SPM terbukti memiliki efek serupa dengan SPM, sehingga dapat digunakan dalam terapi penyakit stroke, jantung, diabetes, dan penyembuhan luka.

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Ameliorative effects of bone marrow derived pancreatic progenitor cells on hyperglycemia and oxidative stress in diabetic rats

et al. 2018

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Stem Cells Therapy in Diabetes Mellitus

Abstract: Human embryonic stem cells (hESCs) have the ability to form cells derived from all three germ layers [23]. hESCs can be induced to differentiate into fetal-like pancreatic cells in vitro using a 33-day, 7-stage protocol [24]. The differentiation protocols for inducing hESCs

Cited by 8 publications

References 91 publications

Mesenchymal stem cells: a future experimental exploration for recession of diabetic nephropathy

Mesenchymal stem cells: a future experimental exploration for recession of diabetic nephropathy

Aplikasi Media Terkondisi Sel Punca Mesensimal dalam Terapi Penyakit Degeneratif dan Penyembuhan Luka

Ameliorative effects of bone marrow derived pancreatic progenitor cells on hyperglycemia and oxidative stress in diabetic rats

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