Currently, STEM (science, technology, engineering, and mathematics) teaching that applies scientific and technical processes is an approach to effectively implementing education in Vietnam. This paper describes the application of scientific and technical processes in teaching STEM topics in a school model associated with production, business, and social life in Vietnam. This experimental study elicited feedback by experts and high school chemistry teachers. Data were collected through expert evaluation forms and questionnaires answered with reference to a Likert scale, and the results were analyzed using quantitative analysis. The research proposed STEM topics associated with production practice and social life for teaching physics, chemistry, and biology in Vietnam. Through the proposed process, we designed and organized 33 STEM education topics associated with production and social life in teaching physics, chemistry and biology. Research results show that teaching STEM topics associated with production practices and social life has clear advantages. Teachers' knowledge and use of STEM topics was found to be at a high level. The study confirmed the effectiveness of applying scientific processes in teaching STEM topics and creating connections between schools and production practices.