Stemona tuberosa prevented inflammation by suppressing the recruitment and the activation of macrophages in vivo and in vitro

Lim, Dahae; Lee, Euijeong; Jeong, Eun-Young; Jang, Young-Pyo; Kim, Jinju

doi:10.1016/j.jep.2014.11.032

Cited by 19 publications

(14 citation statements)

References 40 publications

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“…Our previous study demonstrated that repeated cigarette smoke (CS) exposure provokes inflammation in the lung and colon together, and noted the current body of scholarship showing the link between these two organs (Lim et al, 2017 ). More importantly, we confirmed from the study that macrophages and inflammatory mediators from macrophage including cytokines, chemokine, and proteases are closely related with the inflammatory response in the lung and colon (Lim et al, 2015 , 2017 ). Several studies reported that activated macrophages release inflammatory mediators, contributing to inflammatory progression and tissue destruction in respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, emphysema, and pulmonary fibrosis (Shapiro, 1999 ; Belchamber and Donnelly, 2017 ).…”

Section: Discussionsupporting

confidence: 76%

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung

et al. 2018

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Cigarette smoke (CS) is considered as a major risk factor for pulmonary and intestinal inflammation. CS leads to macrophage infiltration in the mucosae of the lung and colon, inducing the uncontrolled secretion of inflammatory mediators, and thus promoting inflammatory response. In this study, we investigated whether macrophage depletion modulates cigarette smoke (CS)-induced inflammatory response in both the lung and colon. The mice were exposed to CS for 30 min, after which they were rested in a fresh air environment for 30 min. The total duration of exposure to CS was 2 h per day for 4 weeks. Macrophage depletion state was made with the injection of clodronate containing liposome. Individual body weights were measured twice a week, and the mice were sacrificed on day 28. Hematoxylin and eosin (H&E) staining was performed in the lung and colon tissue to determine histological changes. Inflammatory mediators' synthesis was analyzed using ELISA and western blotting. Clodronate liposome treatment ameliorated pathological changes associated with the infiltration of immune cells in the lung and colon. Also, clodronate liposome injected mice showed significantly lower level of inflammatory mediators, including cytokines and chemokine and proteases. Our results indicated that macrophage depletion by clodronate liposome treatment attenuates CS-induced inflammatory response in both the lung and colon.

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Section: Discussionsupporting

confidence: 76%

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung

et al. 2018

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“…The results suggested that the extract attenuated pulmonary inflammatory responses by inhibiting the expression of diverse inflammatory mediators. Preliminary HPLC-ESI-MS analysis let expect that stichoneurine derivatives with stemoninine (21) as major component together with croomine (1) were responsible for the anti-inflammatory effect (Lim et al 2015). In a following study it was shown that tuberostemonine N (56) significantly inhibited the secretion of proinflammatory cytokines and chemokines in bronchoalveolar lavage fluid and decreased alveoli size in lung tissue (Jung et al 2016).…”

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

“…Following the first report on multidrug resistance properties of an ethanolic extract of Stemona aphylla (Limtrakul et al 2007), a series of studies evaluated the synergistic growth inhibitory effect of Stemona alkaloids with cancer chemotherapeutic agents (Chanmahasathien et al 2011a, b;Umsumarng et al 2013Umsumarng et al , 2015Umsumarng et al , 2017Umsumarng et al , 2018. Furthermore, their anti- inflammatory activity was investigated and regarded as an inhibition of the expression of diverse inflammatory mediators (Hosoya et al 2011;Lim et al 2015;Jung et al 2016;Lee et al 2016;Wu et al 2018). The present review also reports on the nematicidal activity (Huang et al 2016;Chen et al 2018) and other miscellaneous properties as well as on the pharmacokinetics of that class of alkaloids (Dong et al 2012;Sun et al 2012;Han et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Structural classification and biological activities of Stemona alkaloids

Greger

2019

Phytochem Rev

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Stemona alkaloids represent a unique class of natural products exclusively known from the three genera Stemona, Stichoneuron, and Croomia of the monocotyledonous family Stemonaceae. Structurally they are characterized by a central pyrroloazepine core usually linked with two butyrolactone rings. The great diversity, comprising 215 derivatives, is created by the formation of additional CC linkages and oxygen bridges together with ring cleavages and eliminations of the lactone rings. Based on biosynthetic considerations they can be grouped into three structural types represented by the croomine, stichoneurine, and protostemonine skeleton. Due to the formation of characteristic terminal lactone rings and the central pyrrolidine ring pandanamine and pandamarilactonine, isolated from Stichoneuron calcicola, were suggested to represent biogenetic precursors. The taxonomically complex S. tuberosa group can be clearly segregated by the formation of stichoneurines, while the other Stemona species are characterized by protostemonine derivatives. Croomine derivatives are more widespread found in both groups and in the genus Croomia. Of chemotaxonomic significance are the different transformations of protostemonine into stemofolines with a cage-type structure or into pyridoazepines characterized by a six-membered piperidine ring. Stimulated by the great interest in the antitussive activity of Stemona alkaloids, differences in transport mechanisms and potencies via different administrative routes were investigated. Follow-up studies on the significant insecticidal activities focused on the mode of action by using biochemical and electrophysiological approaches. Screening for acetylcholinesterase inhibitory properties revealed a much higher potency for stemofoline derivatives compared to pyridoazepines, but showed also significant activity for isomers of stenine with a stichoneurine skeleton. Evaluating synergistic growth inhibitory effects with cancer chemotherapeutic agents stemofoline exhibited the most potent effect in the reversal of permeability glycoprotein-mediated multidrug resistance. The anti-inflammatory activity of some derivatives was identified as an inhibition of the expression of inflammatory mediators. Comparing the diverse bioactivities of Stemona alkaloids stemofoline-type derivatives are the most versatile compounds representing promising lead structures for further development as commercial agents in agriculture and medicine.

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“…45 C57BL/6 mice are good responders to CS and present a well-formed injurious airway or intestinal states. [46][47][48] In our experiment, we exposed C57BL/6 mice to CS using the 3R4F reference cigarette. After three weeks of CS inhalation, we confirmed a significant weight loss in the CSexposed mice.…”

Section: Discussionmentioning

confidence: 99%

Original Research: Extract ofBambusae Caulis in Taeniaminhibits cigarette smoke-induced pulmonary and intestinal inflammation

Lim

Cho

Kim

et al. 2016

Exp Biol Med (Maywood)

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The pulmonary and intestinal systems have several characteristics in common. It is believed that these similarities somehow function to cause pulmonary-intestinal crosstalk during inflammation. Many studies have shown that pulmonary disease occurs in association with inflammatory bowel disease more often than is commonly recognized. Bambusae Caulis in Taeniam, a medicinal herb originated from the inner bark of Phyllostachys nigra var. henosis (Milford) Rendle (Poaceae), has been used to cure fever, diarrhea, and chest inflammation in Korea as well as in China. Cigarette smoke is a well-known risk factor for several inflammatory disorders. In this study, we induced pulmonary and bowel inflammation in mice using cigarette smoke and investigated whether Bambusae Caulis in Taeniam extract modulates the inflammatory response in both the lung and the bowel. C57BL/6 mice were exposed to cigarette smoke for 90 min per day for three weeks, and Bambusae Caulis in Taeniam extract was administered via oral injection 2 h before cigarette smoke exposure. The bronchoalveolar lavage cells were counted and hematoxylin and eosin staining were performed. Levels of inflammatory mediators in lung and large intestine were determined by enzyme-linked immunosorbent assay, real-time polymerase chain reaction, and Western blotting. Our results showed that Bambusae Caulis in Taeniam attenuated cigarette smoke-induced inflammatory response in both the lung and the bowel of mice by inhibiting the production of pro-inflammatory cytokines, chemokines, and protease as well as NF-kB signaling factor. Therefore, we suggest that Bambusae Caulis in Taeniam extract might be a candidate therapeutic agent for inhibiting pulmonary and intestinal inflammation.

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Stemona tuberosa prevented inflammation by suppressing the recruitment and the activation of macrophages in vivo and in vitro

Cited by 19 publications

References 40 publications

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung

Structural classification and biological activities of Stemona alkaloids

Original Research: Extract ofBambusae Caulis in Taeniaminhibits cigarette smoke-induced pulmonary and intestinal inflammation

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