Stenotrophomonas Infection in a Patient with Glucose-6-Phosphate Dehydrogenase Deficiency

Harthan, Aaron A.; Heger, Margaret L.

doi:10.5863/1551-6776-18.2.137

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…For the treatment of S. maltophilia infection, trimethoprim-sulfamethoxazole is still considered as the first-line therapeutic agent of choice, but resistance (2%-25%) has also been reported as an increasing problem for this pathogen [16][17][18]. Alternative agents include piperacillin, fluoroquinolones (e.g., levofloxacin and moxifloxacin), and tetracycline derivatives (e.g., minocycline) [19].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and risk factors of infections caused by Stenotrophomonas maltophilia in a hospital in northwest China

Meng

Zhang

et al. 2014

J Infect Dev Ctries

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Introduction: Stenotrophomonas maltophilia infections have recently increased in importance in China, particularly in intensive care units (ICUs). The aim of this study was to investigate the clinical characteristics and risk factors of S. maltophilia infection in ICU of a hospital in northwest China. Methodology: The characteristics and outcomes of patients with any type of S. maltophilia infection at Shaanxi Provincial People's Hospital, Shaanxi, China, over a two-year period (from July 2011 to June 2013) were studied. S. maltophilia antimicrobial susceptibility was tested with the agar dilution method. The risk factors for all-cause in-hospital mortality were assessed with multivariate logistic regression. Results: Forty patients (median age, 72 years; 77.5% males) with S. maltophilia infection were identified. The main type of infection was lower respiratory tract infection (97.5%); one patient had a bloodstream infection. A total of 97.5% patients were infected with two or more organisms at the same time. The main characteristics of the patients were prolonged use of mechanical ventilation, urethral catheter, and central venous catheter before the infections occurred. The case number of infection was not different in the four seasons. High in vitro sensitivity was observed to minocycline (91.2%), levofloxacin (85.3%), and trimethoprim-sulfamethoxazole (79.4%). Most patients received therapy with a combination of agents. The crude mortality was 50%. By multivariate analysis, low albumin content and hypotension were the independent prognostic factors for mortality. Conclusions: Appropriate antimicrobial treatment had no positive impact on mortality. The impacts of albumin supplements and increasing blood pressure on mortality require further clinical studies.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and risk factors of infections caused by Stenotrophomonas maltophilia in a hospital in northwest China

Meng

Zhang

et al. 2014

J Infect Dev Ctries

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“…A plethora of bacterial and fungal infections was identified in several studies that described the infections in G6PD-deficient patients, among which pneumonia, gastrointestinal, osteomyelitis, cerebrospinal, and septicemia were more common. Most of these infections were caused by Chromobacterium violaceum [ 10 ], Staphylococcus aureus [ 11 ], Escherichia coli [ 12 ], Serratia marcescens [ 13 ], Acinetobacter baumannii [ 14 ], Klebsiella pneumoniae [ 15 ], Pseudomonas aeruginosa [ 16 ], Salmonella species , Staphylococcus epidermidis , Clostridium difficile [ 17 ], and Aspergillus species [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Infections in G6PD-Deficient Hospitalized Patients—Prevalence, Risk Factors, and Related Mortality

Alrahmany

Omar

Harb³

et al. 2022

Antibiotics

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G6PD deficiency is a genetic disease that weakens the immune system and renders affected individuals susceptible to infections. In the Sultanate of Oman resides a high number of recorded G6PD cases due to widespread consanguineous marriage, which may reach 25% of the population. We studied the infection patterns and risk factors for mortality to provide antimicrobial stewardship recommendations for these patients. After obtaining ethical approval, a registry of recorded cases was consulted retrospectively to include G6PD-deficient adult patients admitted to Suhar hospital over 5 years with microbiologically confirmed infections. Patient demographics, health-related information, infection causes, treatment, and clinical outcomes were studied. Data were analyzed to describe infection patterns and risk factors. Several variables, including underlying comorbidities and hospitalization details, such as length of stay, admission to critical care unit, blood transfusion, or exposure to an invasive procedure, were statistically associated with the acquisition of multidrug-resistant and hospital-acquired infections. Meanwhile, these infections were associated with a high mortality rate (28%), significantly associated with the patient’s health status and earlier exposure to antimicrobial treatment due to previous bacterial infection. The high prevalence of G6PD deficiency among the Omani population should alert practitioners to take early action when dealing with such cases during infection that requires hospitalization. Strict infection control measures, Gram-negative empiric coverage, hospital discharge as early as possible, and potent targeted antimicrobial therapy in this patient population can ameliorate the treatment outcomes and should be emphasized by the antimicrobial stewardship team.

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Pharmacogenomics: Basis and Milestones

Cerpa

Varela

Martínez

et al. 2021

The ADME Encyclopedia

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Stenotrophomonas Infection in a Patient with Glucose-6-Phosphate Dehydrogenase Deficiency

Cited by 5 publications

References 15 publications

Clinical characteristics and risk factors of infections caused by Stenotrophomonas maltophilia in a hospital in northwest China

Clinical characteristics and risk factors of infections caused by Stenotrophomonas maltophilia in a hospital in northwest China

Infections in G6PD-Deficient Hospitalized Patients—Prevalence, Risk Factors, and Related Mortality

Pharmacogenomics: Basis and Milestones

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