Stenotrophomonas maltophilia Meningitis Treated With Moxifloxacin

Clinical characteristics of Stenotrophomonas maltophilia meningitis in adults: A high incidence in patients with a postneurosurgical state, long hospital staying and antibiotic use

“…Mixed infection was noted in Case 2. Except Case 4, the clinical manifestations of the other 18 S. maltophilia ABM cases are listed in Table 2, in which fever was the most common, noted in 17 cases (Cases 1-3, 5-7, [9][10][11][12][13][14][15][16][17][18][19]. The other common manifestations were altered consciousness in 6 cases (Cases 1, 5, [10][11][12]19), headache in 6 cases (Cases 2, 6-8, 11, 12) and hydrocephalus in 5 cases (Cases 9, 15-18).…”

“…Among the antibiotics, SMZ-TMP (Cases 3, 5-10, 12, 13, [16][17][18][19] was the most frequently used, followed by the quinolone group including ciprofloxacin, moxifloxacin and levofloxacin (Cases 4, 12-19). Five cases (Cases 13, [16][17][18][19] involved the combination use of SMZ-TMP and one of the above-mentioned quinolones. Even with treatment, two of these 19 S. maltophilia infection-related ABM cases died.…”

“…The Ethics Committee of Chang Gung Memorial Hospital has approved this study (IRB 99-1897C). Meanwhile, the clinical characteristics of 13 reported S. maltophilia ABM cases [6][7][8][9][10][11][12][13][14][15][16][17] were also included for analysis.…”

“…Although it is an important pathogen of hospital-acquired infections, particularly in severely debilitated and immuno-suppressed patients [1][2][3][4][5], S. maltophilia is still an uncommon causative pathogen of adult bacterial meningitis (ABM) and only sporadic case studies have been reported [6][7][8][9][10][11][12][13][14][15][16][17]. Clinically, because of the intrinsic resistance mechanisms against most antimicrobial agents, clinical S. maltophilia strains can develop resistance during treatment [1,2,18,19].…”

Empirical Treatment of Highly Suspected Nontuberculous Mycobacteria Infections Following Aesthetic Procedures

“…The patient showed rapid clinical improvement within 2 weeks and continued oral moxifloxacin for 4 weeks despite the wound being completely healed. The efficient antimicrobial activity of moxifloxacin against S. maltophilia was widely reported in the cases of meningitis and keratitis treatment [ 23 , 24 ]. Moreover, this regimen was effective in three patients who did not demonstrate any evidence of the pathogen.…”