SUMMARYWe report a case of late multiple stent fractures following the deployment of sirolimus-eluting stents (SESs) for diffuse right coronary artery (RCA) stenosis. A 44-year-old male with hyperlipidemia was referred to our hospital for acute myocardial infarction (AMI). Percutaneous coronary intervention (PCI) was performed for total occlusion of the proximal segment of the RCA, and 5 SESs were consecutively implanted for long, diffuse stenotic lesions. A follow-up coronary angiography (CAG) performed 8 months later revealed strut fractures in the middle of all the stents, except the most proximal one. Multislice computed tomography confirmed the locations of the fractured struts inside of the stents. (Int Heart J 2007; 48: 767-772) Key words: Percutaneous coronary intervention, Drug-eluting stent, Stent strut fracture, Intravascular ultrasound, Multislice computed tomography DRUG-eluting stents (DESs) have been used to address in-stent restenosis, a problem that has been plaguing coronary stenting for the past decade. DES implantations have dramatically reduced the incidence of in-stent restenosis, and a number of studies have shown better clinical outcomes following DES implantation when compared with bare-metal stent (BMS) implantation.1-2) However, instent restenosis continues to occur after DES implantation in some cases, and its occurrence has been greatly responsible for limiting a patient's quality of life following percutaneous coronary intervention (PCI). Regarding sirolimus-eluting stents (SESs), previous trials have failed to show their advantage in preventing in-stent or peri-stent restenosis, particularly in patients with end-stage renal disease or insulin-dependent diabetes.3-4) Thus, the problem of in-stent restenosis remains unresolved. In addition, an increasing number of stent fractures followFrom the