Stepping into their shoes: Reducing the actor-observer discrepancy in judgments of infidelity through the experimental manipulation of perspective-taking

Kulibert, Danica; Thompson, Ashley E.

doi:10.1080/00224545.2018.1556575

Cited by 9 publications

(11 citation statements)

References 53 publications

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“…9 ), indicating that phosphorylation of vimentin leads to disassembly of IFs to increase motility of cancer cells through lamellipodia formation [ 49 ]. In addition, phosphomimetics are located at nuclear foci, whereas non-phosphomimetics locate at peri-nuclear foci as a juxta nuclear knot for adhesion [ 53 ], indicating phosphorylation of vimentin by PLK1 increases nuclear translocation to facilitate translocation of p-Smad2/3 for expression of PD-L1 and mesenchymal genes. Thus, phosphorylation of vimentin directly increases cell motility through IFs dynamics and indirectly upregulates gene expression by functioning as a shuttle protein for p-Smad2/3 translocation into the nuclei.…”

Section: Discussionmentioning

confidence: 99%

PLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma

et al. 2021

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The prerequisite function of vimentin for the epithelial–mesenchymal transition (EMT) is not clearly elucidated yet. Here, we show that vimentin phosphorylated by PLK1, triggers TGF-β-signaling, which consequently leads to metastasis and PD-L1 expression for immune suppression in lung adenocarcinoma. The clinical correlation between expression of both vimentin and PLK1, and overall survival rates of patients was significant in lung adenocarcinoma but not in squamous cell carcinoma. The phosphorylation of vimentin was accompanied by the activation of PLK1 during TGF-β-induced EMT in lung adenocarcinoma. Among the several phosphorylation sites determined by phospho-proteomic analysis and the site-specific mutagenesis, the phosphorylation at S339 displayed the most effective metastasis and tumourigenesis with the highest expression of PD-L1, compared with that of wild-type and other versions in both 3D cell culture and tail-vein injection metastasis models. Phosphomimetic vimentin at S339 interacted with p-Smad2 for its nuclear localization, leading to the expression of PD-L1. Clinical relevance revealed the inverse correlation between the survival rates of patients and the expressions of VIM, PLK1, and CD274 in primary and metastatic lung adenocarcinoma. Thus, PLK1-mediated phosphorylation of vimentin activates TGF-β signaling pathway, leading to the metastasis and immune escape through the expression of PD-L1, functioning as a shuttling protein in lung adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

PLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma

et al. 2021

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“…It could also be that the nature of our materials allowed observers to easily imagine themselves in the role of the actors and therefore perceive it from their perspective. Indeed, past research has shown that perspective taking can reduce the discrepancies between actor and observer ratings in other contexts (e.g., Kulibert & Thompson, 2019; Regan & Totten, 1975). Therefore, it is possible that the focus on situational factors for observers in our study was a function of perspective taking.…”

Section: Discussionmentioning

confidence: 99%

From whose perspective? Differences between actors and observers in determining the voluntariness of guilty pleas.

Fessinger¹

2022

Law and Human Behavior

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“…Thus, in contexts other than financial practice judgments, research has shown that although gain and loss considerations could impact people's ethics judgments (Kahneman et al, 1986), and sometimes perspective taking influences judgments directly (e.g. Skorinko et al, 2014), perspective taking effects could be complex, indirect (Caruso et al, 2006;Lucas et al, 2016) and action-specific (Kulibert and Thompson, 2019). Hence, the effects of perspective taking on judgments of financial practices could not be inferred from previous research.…”

Section: Perspective Taking Effects: Literature Background and Hypoth...mentioning

confidence: 99%

“…However, no study has explored how people's perspectives affect their ethics judgments of financial practices. Furthermore, research has demonstrated that perspective taking effects are often action-specific (Kulibert and Thompson, 2019) and hence results about the judgments of non-financial actions cannot be directly generalized to judgments of financial practices.…”

Section: Introductionmentioning

confidence: 99%

Judgments of ethically questionable financial practices: a new perspective

Sobolev

Clunie²

2022

RBF

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Purpose Research has suggested that ethics judgments should be made from an impartial perspective. However, people are often partial about their money. This study aims to investigate the extent to which perspectives – the perspective of those who can gain from the use of a financial practice and the perspective of those who can incur losses due to it – affect lay people’s ethics and legality judgments of the practice. In addition, it asks which factors influence their investment intentions.Design/methodology/approach The study uses a between-participant scenario experiment, in which participants are presented with cases of predatory trading and front running. Each participant is asked to take either a gain or loss perspective through the formulation of the presented cases. Subsequently, all participants make ethics, legality and investment intention judgments.Findings The authors establish that perspectives significantly affect people’s ethics judgments and, to a lesser extent, their legality judgments. People’s investment intentions depend on their perspectives, too, as well as on their financial considerations, ethics judgments, legality judgments and trust.Originality/value Research has focused on relatively stable determinants of people’s ethics judgments of financial practices. This paper shows that the situational prospect of profit can sway lay people’s judgments. When people take the gain perspective, they judge financial practices to be more ethical than when they take the loss perspective. Furthermore, people’s perspectives can distort their legality judgments and influence their investment intentions.

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Stepping into their shoes: Reducing the actor-observer discrepancy in judgments of infidelity through the experimental manipulation of perspective-taking

Cited by 9 publications

References 53 publications

PLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma

PLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma

From whose perspective? Differences between actors and observers in determining the voluntariness of guilty pleas.

Judgments of ethically questionable financial practices: a new perspective

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