Steps during the development of the zebrafish locomotor network

Brustein, Edna; Saint-Amant, Louis; Buss, Robert R.; Chong, Mabel; McDearmid, Jonathan R.; Drapeau, Pierre

doi:10.1016/j.jphysparis.2003.10.009

Cited by 182 publications

(139 citation statements)

References 67 publications

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“…Our results suggest that a mixture of PBDEs and Pb produces neurotoxic effects, although each of them individually did not. Secondary motor neurons are a major cell type that controls swimming behavior in zebrafish during early development, thus interference with either temporal or spatial aspects of axon growth can result in functional defects (Brustein et al, 2003). It is therefore reasonable to suggest that disruptions in structure or function of spinal motoneurons could result in altered swimming behavior in zebrafish larvae.…”

Section: Discussionmentioning

confidence: 99%

Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae

et al. 2016

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“…This serotonergic cell population represents a feature conserved in all groups of fishes studied and is variably present in amphibians, reptiles, and birds, whereas mammals lack spinal 5-HT-ir cells [Sako et al, 1986b;Kiehn et al, 1992;Branchereau et al, 2000;Lillesaar, 2011;. These cells may provide substantial intrinsic innervation of the spinal cord [Wallen et al, 1989;Stuesse and Cruce, 1991;Adrio et al, 1999;Chiba and Oka, 1999;Brustein et al, 2003b;Barreiro-Iglesias et al, 2008;Carrera et al, 2008;Gabriel et al, 2009;Lillesaar, 2011], although part of the 5-HT-ir fibers may arise from the inferior raphe, such as in elasmobranches, lungfishes, and amphibians [Ritchie et al, 1984;Ronan and Northcutt, 1985;Tan and Miletic, 1990], or at more rostral hindbrain levels, such as in lampreys [Brodin et al, 1986;Barreiro-Iglesias et al, 2008]. This descending serotonergic projection and the local innervation may play important roles in the modulation of locomotion at spinal levels, as has been demonstrated in lampreys and zebrafish [Wallén et al, 1989;Brustein et al, 2003a;Gabriel et al, 2009].…”

Section: Spinal Cordmentioning

confidence: 99%

Organization of the Serotonergic System in the Central Nervous System of Two Basal Actinopterygian Fishes: the Cladistians Polypterus senegalus and Erpetoichthys calabaricus

López¹,

González²

2014

Brain Behav Evol

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Cladistians (Polypteriformes) are currently considered basal to other living ray-finned fishes (actinopterygians), and their brain organization is therefore critical to providing information about the primitive neural characters that existed in the earliest ray-finned fishes. The organization of the serotonergic system in the brain has been carefully analyzed in most vertebrate groups, and in the present study we provide the first detailed information on the distribution of serotonergic cell bodies and fibers in the central nervous system of representative species of the two extant genera of cladistians, i.e. Polypterus senegalus and Erpetoichthys calabaricus, by means of immunohistochemistry against serotonin (5-HT). Distinct groups of immunoreactive cells were detected in the preoptic area, the hypothalamic paraventricular organ, the pineal organ, the pretectal region, the long column of the raphe in the rhombencephalic midline, the spinal cord, and amacrine cells in the inner nuclear layer of the retina. Fiber labeling was widely distributed in all main brain subdivisions but was more abundant in distinct pallial and subpallial areas, the preoptic area, the thalamus, the optic tectum, the tori semicircularis and lateralis, the rhombencephalic reticular formation, the nucleus of the solitary tract, and the dorsal aspect of the spinal cord. Our analysis makes it possible to establish which serotonergic structures characterized the earliest ray-finned fishes, and a comparison of these results with those from other classes of vertebrates, including a segmental analysis to correlate cell populations, reveals that most characteristics, such as the presence of serotonergic cells in the preoptic area and the basal hypothalamus, are preserved in all anamniotes. However, this system seems to be reduced in amniotes, mainly mammals, although important features are shared, such as the presence of serotonergic cells in the pineal organ, the retina, and the raphe nuclei.

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“…During development, zebrafish progress through three behavior types: spontaneous tail coiling beginning at 17 hpf completely directed by the spinal cord; response to touch at 21 hpf coordinated by the spinal cord and the hindbrain; and swimming at 27 hpf in the dechorionated embryo requiring both functional nervous and muscular systems (Brustein et al, 2003). All three milestones regularly are assessed and impacted in toxicology screens.…”

Section: Toxicity Causing Behavioral Changesmentioning

confidence: 99%

Developmental toxicity screening in zebrafish

McCollum

Ducharme

Bondesson

et al. 2011

Birth Defects Research Part C: Embryo Today: Reviews

140

101

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Given the ever-increasing toxic exposure ubiquitously present in our environment as well as emerging evidence that these exposures are hazardous to human health, the current rodent-based regulations are proving inadequate. In the process of overhauling risk assessment methodology, a nonrodent test organism, the zebrafish, is emerging as tractable for medium- and high-throughput assessments, which may help to accelerate the restructuring of standards. Zebrafish have high developmental similarity to mammals in most aspects of embryo development, including early embryonic processes, and on cardiovascular, somite, muscular, skeletal, and neuronal systems. Here, we briefly describe the development of these systems and then chronicle the toxic impacts assessed following chemical exposure. We also compare the available data in zebrafish toxicity assays with two databases containing mammalian toxicity data. Finally, we identify gaps in our collective knowledge that are ripe for future studies.

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Steps during the development of the zebrafish locomotor network

Cited by 182 publications

References 67 publications

Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae

Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae

Organization of the Serotonergic System in the Central Nervous System of Two Basal Actinopterygian Fishes: the Cladistians <b><i>Polypterus senegalus</i></b> and <b><i>Erpetoichthys calabaricus</i></b>

Developmental toxicity screening in zebrafish

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