Stepwise Appearance of Sperm-Specific Antigens in Rats and Their Disappearance after Fertilization

Isojima, Shinzo; Li, Tien Shun

doi:10.1016/s0015-0282(16)36856-x

Cited by 13 publications

(4 citation statements)

References 1 publication

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“…The antiserum so absorbed did not give a cross reaction with homogenates of liver and most of the other organs. Isojima & Li (1968) have also made a similar observation.…”

Section: Methodssupporting

confidence: 63%

Immunological Studies With Rat Testis: Antigenic Characterization

Gunaga¹,

Sheth²,

Rao³

1970

Reproduction

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Testes of Wistar rats contain at least three organ-specific antigens as revealed by the gel diffusion analysis. Antiserum to rat testis absorbed with serum and liver cross-reacts with the extracts of epididymis, brain and ovary. Heating at over 60\ s=deg\ C destroys the combining power of all the three testis-specific antigens. Two of the three organ\x=req-\ specific antigens of the Wistar strain of rats are common to two antigens present in the testes of man, sheep, rabbit, hamster, guinea-pig and mouse.

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“…The antiserum so absorbed did not give a cross reaction with homogenates of liver and most of the other organs. Isojima & Li (1968) have also made a similar observation.…”

Section: Methodssupporting

confidence: 63%

Immunological Studies With Rat Testis: Antigenic Characterization

Gunaga¹,

Sheth²,

Rao³

1970

Reproduction

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“…Dukelow, Chernoff, Pinsker & Williams (1966) suggested that the decapacita¬ tion factor consisted of a protein-carbohydrate complex bound to the sperm head by sialic acid units. A sperm-coating antigen has been investigated in the guinea-pig (Henle & Henle, 1940;Katsh & Colo, 1959), rat (Isojima & Li, 1968), mouse (McLaren, 1964;Bell, 1969) and rabbit (Weil,I960).…”

Section: Introductionmentioning

confidence: 99%

Studies on Sperm Capacitation

Aonuma¹,

Mayumi²,

Suzuki³

et al. 1973

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During incubation of guinea-pig spermatozoa in Ca-free Krebs-Ringer phosphate buffer, substances were released into the medium which were subsequently separated on Sephadex G-200 into two major fractions, Fr. I and Fr. II. The macromolecular Fr. I increased with sperm maturation and the fraction was shown to possess four different antigens. The amount of Fr. I. released from spermatozoa during incubation in the uterus was apparently influenced by the hormonal environment of the female reproductive tract. The fraction showed decapacitating activity, and decapacitated spermatozoa treated with Fr. I were capable of recapacitation after a second uterine incubation period. It was concluded that Fr. I was the decapacitation factor in guinea-pig semen.

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“…l Female response to the antigens of semen Spermatozoaexpresstissuespecific [41,47,62,82,99], male specific [8,55,59] blood group [20,31,37], and histocompatibility antigens [32,34,38,95]. Since the initial work by LANDSTEINER [63] and METCHNIKOFF [70], the distinctive immunological properties found in the components of the male ejaculate have been considered to contribute to harmful sensitization phenomena [88] and apart from the possibility of explaining some cases of infertility, these phenomena have been used to effect the development of an immunological means of fertility control [15].…”

mentioning

confidence: 99%

Review article

1976

Journal of Perinatal Medicine

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Stepwise Appearance of Sperm-Specific Antigens in Rats and Their Disappearance after Fertilization

Cited by 13 publications

References 1 publication

Immunological Studies With Rat Testis: Antigenic Characterization

Immunological Studies With Rat Testis: Antigenic Characterization

Studies on Sperm Capacitation

Review article

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