“…Histopathology confirmed the presence of a full thickness perforation approximately 50 mm in length, with surrounding ischaemic necrosis of the mucosa and a massive faecaloma, confirming the diagnosis of stercoral perforation associated with ischaemia. Although there have been limited case reports of stercoral perforation described in schizophrenic patients requiring Clozapine and other antipsychotics that have a constipating effect [ 6 , 10 ], Ms IW had been on long-term Clozapine and her stercoral perforation was believed to be associated with her comorbidities and adjuvant chemotherapy, not just associated with Clozapine.…”