Stereo-isomeric nitrates in the treatment of angina pectoris

Riseman, Joseph E. F.; Koretsky, Sidney; Altman, George E.

doi:10.1016/0002-9149(65)90458-3

Cited by 30 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with other pharmacological effects of these agents (Riseman, Koretsky & Altman, 1965;Krantz, Carr, Forman & Cone, 1940).…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Effect of organic nitrates on myocardial oxygen consumption in vitro

Levy

1970

British J Pharmacology

View full text Add to dashboard Cite

Summary1. Mannitol hexanitrate (MANHN), iditol hexanitrate and sorbitan tetranitrate, all at 442 ,uM, stimulate oxygen uptake by isolated rabbit atrial tissue. 2. At the same concentration, glyceryl trinitrate decreased oxygen uptake, while isosorbide dinitrate and erythrityl tetranitrate had no effect. 3. No simple correlation was found between the lipoid solubility or per cent nitration of these compounds and their effects on oxygen uptake. 4. The stimulating effect of MANHN and its possible role as an uncoupler of oxidative phosphorylation is discussed. IntroductionIn recent years there has been increased emphasis on the direct and indirect myocardial actions of organic nitrates to explain their therapeutic actions in man (Rowe, 1968). While many of the data in animals and man point to the fact that nitrates are capable of reducing myocardial oxygen consumption (Rowe, 1968), the direct cellular mechanism of this effect, if any, is not completely understood. Moreover, little information is available comparing the actions of a variety of organic nitrates on cardiac muscle metabolism.In order to provide further information on the basic actions of organic nitrates on cardiac metabolism, the following problems were studied: (a) the direct effects of various organic nitrates on basal myocardial oxygen uptake (q02); (b) the structure-activity-relations for these agents in terms of their effects on myocardial oxygen consumption.

show abstract

“…This is consistent with other pharmacological effects of these agents (Riseman, Koretsky & Altman, 1965;Krantz, Carr, Forman & Cone, 1940).…”

Section: Discussionsupporting

confidence: 90%

“…The data show that no pattern of in vitro activity can be correlated with the number of nitrate groups, or percentage nitration of the molecule. This is consistent with other pharmacological effects of these agents (Riseman, Koretsky & Altman, 1965;Krantz, Carr, Forman & Cone, 1940).…”

Section: Discussionsupporting

confidence: 90%

Effect of organic nitrates on myocardial oxygen consumption in vitro

Levy

1970

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…[17] MHN was used in detonators and even explosive rivet composition during World War II, before being replaced by more stable compositions [18]. Like NG and PETN, MHN acts as a vasodilator and in the past has been used in the treatment of angina pectoris [19]. Recently, a co‐crystal of MHN with 1‐nitronaphthalene was reported; it had slightly decreased sensitivity but also poorer performance [20].…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Hexanitrate Esters of Sugar Alcohols

McLennan

Brown-Nash

Busby

et al. 2021

Propellants Explo Pyrotec

View full text Add to dashboard Cite

The hexanitrates of the six‐carbon sugars mannitol and sorbitol were prepared and studied to gain insight in their relative stabilities. Synthesis and characterization of these materials resulted in the identification of two new crystalline polymorphs, one for each hexanitrate. Mannitol hexanitrate (MHN) exposed to elevated temperatures exhibited a different structure when measured by x‐ray diffraction (XRD) and Raman spectroscopy; however, no differences were observed in the thermal behavior. Sorbitol hexanitrate (SHN) has two distinct crystalline polymorphs that result in different melting behavior and differences in Raman and XRD. Thermal stability of these hexanitrates was also examined; despite being isomers, SHN and MHN differ in their long‐term thermal stability.

show abstract

Prophylactic Therapy of Angina Pectoris With Organic Nitrates: Relationship of Drug Efficacy and Clinical Experimental Design

Stipe

Fink

1973

The Journal of Clinical Pharmacology and New Drugs

View full text Add to dashboard Cite

Stereo-isomeric nitrates in the treatment of angina pectoris

Cited by 30 publications

References 14 publications

Effect of organic nitrates on myocardial oxygen consumption in vitro

Effect of organic nitrates on myocardial oxygen consumption in vitro

Characterization of the Hexanitrate Esters of Sugar Alcohols

Prophylactic Therapy of Angina Pectoris With Organic Nitrates: Relationship of Drug Efficacy and Clinical Experimental Design

Contact Info

Product

Resources

About