Stereochemical modulation of ketyl radical cyclization enabled by pyridine-boryl radicals: catalytic diastereoselective synthesis of trans-2-alkyl-1-indanols

Abstract

Stereochemical modulation of ketyl radical cyclization was achieved by taking advantage of the pyridine-boryl radical, which leaves the synthetically modifiable boronate moiety near the reacting center during the stereo-determining cyclization step.