Stereochemical Strategy Advances Microbially Antiadhesive Cotton Textile in Safeguarding Skin Flora

Abstract

Microbial contamination on cotton textiles (CT) negatively affects people's health as well as the textile itself during use and storage. Using antimicrobial CT in a body‐safe manner is currently still a challenge because it is difficult to balance killing microbes and protecting skin flora. Herein, a borneol‐decorated CT (BDCT) through coupling of borneol 4‐formylbenzoate molecules onto the amino‐modified CT is reported. This BDCT shows strong and broad‐spectrum microbially antiadhesive activities against gram‐positive bacteria (Staphylococcus aureus and S. epidermidis), gram‐negative bacteria (Escherichia coli and Pseudomonas aeruginosa), and fungi (Aspergillus niger, Mucor racemosus, and Candida albicans). Because of its unique stereochemical microbial antiadhesion mechanism, BDCT is harmless to skin flora. In addition, BDCT exhibits prominent durability of microbially antiadhesive capability by bearing 50 times of accelerated laundering. Therefore, this stereochemical BDCT strategy shows great potential for applications in the new generation of textiles, food packaging, and medical protection.

Durable antimicrobial adhesion cotton textiles based on borneol-based anti-MRSA finishing agent

“…According to the modified ISO 10993.10-2010 standard method (Chen et al 2011;Xu et al 2019a;Zhang et al 2018), skin sensitization of NCO-B-CT was evaluated. Three healthy male albino rabbits (2.0-2.5 kg) were purchased from the Beijing Vital River Experimental Animal Technology Co., Ltd., and they were treated and cared for in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH Publications No.…”

“…Meanwhile, because superbugs primarily stem from antibiotic misuse, the strategy of antimicrobial adhesion is believed to be a superior choice for the development of antimicrobial CT, which can prevent bacteria from evolving into superbugs, as well as resist the adhesion and further proliferation or contamination of superbugs. As an alternative, a new surface stereochemistry strategy for antimicrobial adhesion was proposed (Li et al 2017;Li et al 2021;Luo et al 2014;Shi et al 2015;Sun et al 2016;Xin et al 2020;Xu et al 2018;Xu et al 2019a), which can control the microbial adhesion behavior by utilizing the "chiral taste" of microbes (Wang et al 2010;Wang et al 2012;Xie et al 2020). In this strategy, surface stereochemistry plays a significant role in regulating microbial behavior during the interaction between microorganisms and material surfaces, rather than hydrophobicity or the release of bactericides (Lin et al 2017).…”

“…In this strategy, surface stereochemistry plays a significant role in regulating microbial behavior during the interaction between microorganisms and material surfaces, rather than hydrophobicity or the release of bactericides (Lin et al 2017). It is therefore considered to be a soft management and control of microbes, rather than kill them (Xu et al 2019a). Our previous studies demonstrated that chiral borneol based polymers that can control microbial adhesion due to their "chiral taste" (Luo et al 2014), and this property is also suitable for CT decoration.…”

“…Borneol decorated antimicrobial CT (BDCT) has been developed through a two-step method using siloxane as linker, which exhibited antimicrobial adhesion properties owing to the influence of the surface bicyclicstereochemistry of borneol, rather than hydrophobicity (Xu et al 2019a). However, the siloxane tends to self-condensate during the first modification and the two-step finishing process is not efficient.…”

Non-Leaching, Rapid Bactericidal and Biocompatible Polyester Fabrics Finished with Benzophenone Terminated N-halamine

“…However, pathogenic bacteria can proliferate rapidly on porous PET fabrics to form bacterial plaques/biofilms, resulting in irreversibly damaging their appearance, adversely affecting human health, and increasing cross-infection in public environments [ 2 ], since bacterial infection is one of the most serious threat to global safety especially drug-resistant bacteria [ 3 – 6 ]. To endow fabrics with antibacterial activity, ciprofloxacin [ 7 ], metal salts and nanoparticles [ 8 – 10 ], metallic oxide [ 11 ], rose Bengal [ 12 ], chitosan [ 13 – 15 ], betaine [ 16 , 17 ], surface stereochemistry [ 18 ], quaternary ammonium salt(QAS) [ 19 – 21 ]. dopamine-menthol [ 22 ], guanidine [ 23 , 24 ], and N -halamine [ 25 – 27 ] have been developed, and impressive achievements have been gained.…”