Stereochemistry and fungitoxicity of complexes of p-anisaldehydethiosemicarbazone with Mn(II), Fe(II), Co(II) and Ni(II)

The coordination and organometallic chemistry of metal±nitrogen-and metal±sulfur-bonded compounds have come to occupy a prominent position in research due to their economical importance in the field of agricultural, medicinal and industrial chemistry. Although Schiff bases of ferrocene derivatives and their metal complexes with lanthanide and transition metal ions have been synthesized and some of their structures characterized, their interaction with main group metal ions and the formation of their coordination complexes are subjects of current interest. This communication deals with a description of synthetic procedure and structural characterization on the basis of analytical and spectroscopic techniques of a new class of coordination compounds of organotin(IV) and organosilicon(IV) with a sulfur-containing ligand moiety derived by the condensation of 1-acetylferrocene and thiosemicarbazide. Finally, attempts have been made to establish a correlation between a variety of biointeraction activities, including antimicrobial activity and antifertility activity, on male rats and the structures of the resulting products on the basis of different constituents and chemical phenomena.

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“…The growth inhibition percentage was calculated on the basis of the average diameter of the fungal colony according to 38 …”

Section: Antifungal Activity (Radial Growth Method)mentioning

confidence: 99%

Studies of biologically potent organotin(IV) and organosilicon(IV) complexes of a sulfur donor ligand derived from 1‐acetylferrocene

Singh

Joshi

Gajraj

et al. 2002

Applied Organom Chemis

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“…The enhanced activity of the complexes over the ligands can be explained on the basis of chelation theory. 41,42 It is known that chelation makes the ligand a more powerful and potent bactericidal agent, thus killing more of the bacteria than the ligand. The enhancement in the activity may be rationalized on the basis that ligands mainly possess an azomethine (C = N) bond.…”

Section: In Vitro Antimicrobial Activitymentioning

confidence: 99%

Synthesis, spectroscopic characterization, and biological screening of binuclear transition metal complexes of bicompartmental Schiff bases containing indole and resorcinol moieties

Karekal¹,

Mruthyunjayaswamy²

2013

Turk J Chem

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A series of binucleating Cu(II), Ni(II), and Zn(II) complexes of bicompartmental ligands with ONO donors were prepared. The ligands were synthesized by the condensation of 5-substituted-3-phenyl-1 H -indole-2-carboxyhydrazides and 4,6-diacetylresorcinol. The newly synthesized ligands and their complexes were characterized by elemental analysis and various spectral studies like IR, 1 H NMR, ESI-mass, UV-Vis, ESR, thermal studies, magnetic susceptibility, molar conductance, and powder-XRD data. All the complexes were binuclear and monomeric in nature. Cu(II) complexes have octahedral geometry, whereas Ni(II) and Zn(II) complexes have square planar and tetrahedral geometry, respectively.The redox property of the Cu(II) complex was investigated by electrochemical method using cyclic voltammetry. In order to evaluate the effect of metal ions upon chelation, both the ligands and their metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleaving capacity of all the complexes was analyzed by agarose gel electrophoresis.

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“…The results are shown in Table 5. The increased activity of the complexes compared to the free ligands can be explained on the bases of chelation theory 32 . Chelation reduces the polarity of the metal ion; mainly because of the partial sharing of its positive charge with donor groups and the possible π-electron delocalization over the whole chelate ring.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Synthesis, Complexation and Biological Activity of New Isatin Schiff_bases

Sallam¹,

Ibrahim²,

Anwar³

2012

J. Chil. Chem. Soc.

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Some new Schiff-bases derived from condensation of 3-hydrazono-2-oxo-2,3-dihydroindol-1-yl)-acetic acid hydrazide (3) with benzaldehyde, p-methoxybenzaldehyde and p-chlorobenzaldehyde have been synthesized in high yields via refluxing in EtOH in the presence of catalytic amount of acetic acid. The synthesized compounds have been characterized by elemental analysis, IR, I H-NMR and mass spectra. Cu(II), Zn(II), Mn(II) and Fe(III) complexes of the synthesized compounds were prepared and characterized by elemental analysis, conductivity measurements, IR, UV-Vis. spectra and magnetic moment measurements. TGA and DTA confirm the chemical formulation of the complexes and their thermal decomposition were evaluated. Antimicrobial activity of the synthesized compounds have been screened using the desk diffusion method with different strains of bacteria: Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli and Proteus volgaris were used.

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Stereochemistry and fungitoxicity of complexes of p-anisaldehydethiosemicarbazone with Mn(II), Fe(II), Co(II) and Ni(II)

Cited by 111 publications

References 4 publications

Studies of biologically potent organotin(IV) and organosilicon(IV) complexes of a sulfur donor ligand derived from 1‐acetylferrocene

Studies of biologically potent organotin(IV) and organosilicon(IV) complexes of a sulfur donor ligand derived from 1‐acetylferrocene

Synthesis, spectroscopic characterization, and biological screening of binuclear transition metal complexes of bicompartmental Schiff bases containing indole and resorcinol moieties

Synthesis, Complexation and Biological Activity of New Isatin Schiff_bases

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