Stereological analysis of the muscle‐tendon junction in the aging mouse

Trotter, John A.; Samora, A.; Hsi, K.; Wofsy, Carla

doi:10.1002/ar.1092180310

Cited by 100 publications

(10 citation statements)

References 20 publications

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“…A variety of structural proteins localized at the ends serve this purpose (Baker et al, 1994;Tidball, 1991Tidball, , 1992Tidball, , 1994. The normally complex morphology of the myotendinous junction can be greatly altered by myopathies (Desaki, 1992;Tidball, 1993, Law et al, 1994) and aging (Trotter et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Myosin heavy chain expression within the tapered ends of skeletal muscle fibers

et al. 1995

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Section: Discussionmentioning

confidence: 99%

Myosin heavy chain expression within the tapered ends of skeletal muscle fibers

et al. 1995

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“…That these detergent-resistant filaments transmit Model: C =right circular cylinder; P = paraboloid; o>=degree of orientation (not shapespecific) [see Eisenberg andMilton. 1984. andHsi. 1987|.…”

Section: Compositionmentioning

confidence: 99%

Functional Morphology of Force Transmission in Skeletal Muscle

Trotter

1993

Cells Tissues Organs

149

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The work done by the contractile proteins of muscle in accelerating, decelerating, or maintaining the positions of skeletal elements requires the efficient transmission of tension across the surface membranes of the fibers. The most widely studied sites of tension transmission are the ends of muscle fibers where they contact either connective or epithelial tissues. In most animals, regardless of phylum, muscle fiber ends are characteristically folded, producing a junctional interface that significantly reduces the absolute value of stress applied to the cell membrane, insures that the principle stress vector at the cell membrane is shear rather than tension, and minimizes stress concentrations. The morphological and molecular similarities of muscle-tendon junctions (MTJs) in different animals suggest that the problem of creating a strong adhesive joint between a muscle fiber and a tissue of dissimilar physical properties is essentially the same for all muscles, and that the solution arose early in evolution. In addition to those muscle fiber ends that occur where fibers contact dissimilar tissues, there are intramuscular fiber terminations that consist either of folded cell-cell junctions similar to the fasciae adherentes of cardiac muscle, or of gradually tapering fiber ends. Both sorts of intramuscular ends occur in those vertebrate muscles in which the individual muscle fibers are too short to reach from the tendon of origin to the tendon of insertion. In series-fibered muscles in which the fiber ends are tapered, tension is transmitted from contractile proteins to endomysial collagen fibrils across the fiber membranes. The endomysium of such muscles is an essential series-elastic element. The existing evidence suggests that tension transmission is a general property of muscle cell surfaces, and that specific junctional morphologies are the results of dynamic interactions between muscle cells and the tissues to which they adhere.

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“…Macro-level architectural data are available on a large number of skeletal muscles, most of which Windhorst et al have recognized. Although detailed data have been presented on the morphological features of muscle fibers (Loeb et al 1987; and motor units (Ounjian et al 1987), as well as the structural features of fiber-to-tendon interfaces (Tidball & Daniel 1986;Trotter et al 1987), the available data are insufficient to explain the stress-strain properties of whole muscles. Considerable progress has been made in defining the way forces can be transmitted at the musculotendinous junc-tions.…”

Section: Motor Unit Architecture and Interfiber Matrix In Sensorimotomentioning

confidence: 99%

On the function of muscle and reflex partitioning

Hamm²,

1989

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Studies have shown that in the mammalian neuromuscular system stretch reflexes are localized within individual muscles. Neuromuscular compartmentalization, the partitioning of sensory output from muscles, and the partitioning of segmental pathways to motor nuclei have also been demonstrated. This evidence indicates that individual motor nuclei and the muscles they innervate are not homogeneous functional units. An analysis of the functional significance of reflex localization and partitioning suggests that segmental control mechanisms are based on subdivisions of motor nuclei–muscle complexes. A partitioned organization of segmental control mechanisms could utilize (1) the potential functional diversity of muscle fiber types, (2) the variety of mechanical actions of individual muscles arising from their distributed origins and insertions, and (3) diverse architectural features such as intramuscular variations in pinnation and complex in-series and in-parallel arrangements of muscle fibers. The differentiated activity observed in some muscles during natural movements also calls for localized segmental control mechanisms. Partitioning may also play a role in mechanical interactions between contracting motor units and in increasing the stability of neuromuscular systems. The functional advantages of reflex localization and partitioning suggest they are probably common features of segmental systems, whose organization reflects the structure and function of their associated neuromuscular systems.

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Stereological analysis of the muscle‐tendon junction in the aging mouse

Cited by 100 publications

References 20 publications

Myosin heavy chain expression within the tapered ends of skeletal muscle fibers

Myosin heavy chain expression within the tapered ends of skeletal muscle fibers

Functional Morphology of Force Transmission in Skeletal Muscle

On the function of muscle and reflex partitioning

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