Stereological evaluation of the volume and volume fraction of newborns’ brain compartment and brain in magnetic resonance images

Nisari, Mehtap; Ertekın, Tolga; Özçelik, Özlem; Çinar, Şerife; Doğanay, Selim; Acer, Niyazi

doi:10.1007/s00276-012-0971-6

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…Our age corrected global and structural measurements for term controls closely match post-mortem volume measurements reported by Nisari et al [38] and in vivo MRI measurements by Clouchoux and colleagues [39] but are smaller than those reported by Thompson et al [7] in neonates. These discrepancies may relate to study differences in subject race, image acquisition, or post-processing methods utilized.…”

Section: Discussionsupporting

confidence: 88%

Perinatal Factors and Regional Brain Volume Abnormalities at Term in a Cohort of Extremely Low Birth Weight Infants

et al. 2013

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Our objective was to investigate diverse clinical antecedents of total and regional brain volume abnormalities and white matter hyperintensity volume on term MRI in extremely low birth weight (birth weight ≤1000 g) survivors. A consecutive cohort of extremely low birth weight infants who survived to 38 weeks postmenstrual age (n = 122) and a control group of 16 healthy term newborns underwent brain MRI at term-equivalent age. Brain volumes were measured using semi-automated and manual segmentation methods. Using multivariable linear regression, clinical antecedents were correlated with volumes of total brain tissue, white matter hyperintensities, and regional tissues/structures, adjusted for age at MRI, total cranial volume, and total tissue volume. Regional brain volumes were markedly reduced in extremely low birth weight infants as compared to term newborns (relative difference range: −11.0%, −35.9%). Significant adverse clinical associations for total brain tissue volume included: small for gestational age, seizures, caffeine therapy/apnea of prematurity, duration of parenteral nutrition, pulmonary hemorrhage, and white matter injury (p<0.01 for each; relative difference range: −1.4% to −15.0%). Surgery for retinopathy of prematurity and surgery for necrotizing enterocolitis or spontaneous intestinal perforation were significantly associated with increasing volume of white matter hyperintensities. Regional brain volumes are sensitive to multiple perinatal factors and neonatal morbidities or interventions. Brain growth measurements in extremely low birth weight infants can advance our understanding of perinatal brain injury and development.

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Section: Discussionsupporting

confidence: 88%

Perinatal Factors and Regional Brain Volume Abnormalities at Term in a Cohort of Extremely Low Birth Weight Infants

et al. 2013

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“…the quantitative evaluation of brain atrophy because their superior contrast resolution facilitates discrimination of the grey and white matter 31 . The in vivo comparative morphological research collects data from the newborn's total brain, cerebrum, cerebellum and bulbus/pons to try to explain the origin of neurodevelopmental mental disorders 30 . The volume of the brain, cerebellum and brain stem was also observed in the young subjects 33 .…”

Section: Resultsmentioning

confidence: 99%

Recent developments and the importance of the volume estimation in biomedical sciences

Akosman¹

2013

OA Anatomy

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Introduction Recently, scientists who performed morphological, comparative and experimental studies have tried to get more efficient and accurate information from the interested tissue. The volume estimation is part of this information and an important criterion for the biomedical sciences. It increases the confidence in the data obtained. The volumetric change is an indicator of an organ's health status. It is also important in the clinical diagnosis of a tumour, therapy planning and control of the tumour's growth. The important data obtained using the Cavalieri principle is considered the best volume estimation method. This method, a stereological tool, allows precise estimates about the related object. Scientists and clinicians both use this method under in vivo and in vitro conditions. The method could combine in vivo by computed tomography and magnetic resonance images and in vitro after the classical histological tissue processing. The aim of this article was to discuss the recent developments and the importance of the volume estimation in biomedical sciences. Methodology The Cavalieri principle could estimate an object's volume under in vitro and in vivo conditions. In vitro estimations-First, the tissue is sliced at a random starting point at parallel and equal intervals. Then, the surface areas of these slices (just one and the same side of each slice) are measured by a randomly superposed point grid. The point counting procedure could be done on a computer loaded with stereology software. In vivo estimations-This measurement is done on magnetic resonance and computed tomography images. The parallel and equally sliced images of the related objects are obtained from the magnetic resonance and computed tomography. At the monitor, the software places the point grid on these images and the estimations are calculated. Conclusion The Cavalieri principle estimates the total volume of an organ and its subcomponents more accurately and precisely than the other methods. It runs simply and easily and produces efficient results.

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“…Those studies have used Cavalieri's principle, a stereological method for organ volume measurement [1,2,9]. The volumes of organs such as heart [27], liver [33], prostate [3], ventricle [22], brain [24], and also the volume of foetus [29], have been measured using MR imaging and Cavalieri's principle.…”

Section: Discussionmentioning

confidence: 99%

Estimation of spleen volume and surface area of the newborns’ cadaveric spleen using stereological methods

Sağiroğlu

Acer²,

Ertekın³

et al. 2014

Folia Morphol

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Stereological evaluation of the volume and volume fraction of newborns’ brain compartment and brain in magnetic resonance images

Cited by 10 publications

References 32 publications

Perinatal Factors and Regional Brain Volume Abnormalities at Term in a Cohort of Extremely Low Birth Weight Infants

Perinatal Factors and Regional Brain Volume Abnormalities at Term in a Cohort of Extremely Low Birth Weight Infants

Recent developments and the importance of the volume estimation in biomedical sciences

Estimation of spleen volume and surface area of the newborns’ cadaveric spleen using stereological methods

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