Stereoselective Construction of Eight‐Membered Oxygen Heterocycles by Brook Rearrangement‐Mediated [3 + 4] Annulation.

Abstract

The new approach involves combination of β-substituted acryloylsilanes and enolates of 6-oxacyclohept-2-en-1-one. A unique feature of this annulative approach is its capacity to generate eight-membered ring systems containing useful functionalities for further synthetic elaboration from readily available three-and four-carbon components. -(SAWADA, Y.; SASAKI, M.; TAKEDA*, K.; Org. Lett. 6 (2004Lett. 6 ( ) 13, 2277Lett. 6 ( -2279 Dep. Synth. Org. Chem., Grad. Sch. Med. Sci., Hiroshima Univ., Minami, Hiroshima 734, Japan; Eng.) -Steudel 43-173