Stereoselective Radical Acylfluoroalkylation of Bicyclobutanes via N‐Heterocyclic Carbene Catalysis
Chuyu Xiao,
Jing‐Ran Shan,
Wen‐Deng Liu
et al.
Abstract:Cyclobutanes are prominent structural components in natural products and drug molecules. With the advent of strain‐release‐driven synthesis, ring‐opening reactions of bicyclo[1.1.0]butanes (BCBs) provide an attractive pathway to construct these three‐dimensional structures. However, the stereoselective difunctionalization of the central C–C σ‐bonds remains challenging. Reported herein is a covalent‐based organocatalytic strategy that exploits radical NHC catalysis to achieve diastereoselective acylfluoroalkyla… Show more
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