Stereoselective screening for and confirmation of urinary enantiomers of amphetamine, methamphetamine, designer drugs, methadone and selected metabolites by capillary electrophoresis

Ramseier, Andreas; Caslavska, Jitka; Thormann, Wolfgang

doi:10.1002/(sici)1522-2683(19990901)20:13<2726::aid-elps2726>3.0.co;2-6

Cited by 57 publications

(32 citation statements)

References 32 publications

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“…[13][14][15][16][17][18] and in urine. [19][20][21][22][23][24] However, these methods for amphetamines in urine require a procedure of extraction from urine and are unsatisfactory with respect to the need for rapid analyses. We developed a method for the chiral analysis of MA and its metabolites by CE/diode-array detection with direct injection of urine.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Chiral Analysis of Methamphetamine and its Metabolites by Capillary Electrophoresis/Mass Spectrometry with Direct Injection of Urine

Iio

Chinaka

Takayama

et al. 2005

JOURNAL OF HEALTH SCIENCE

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Section: Introductionmentioning

confidence: 99%

Simultaneous Chiral Analysis of Methamphetamine and its Metabolites by Capillary Electrophoresis/Mass Spectrometry with Direct Injection of Urine

Iio

Chinaka

Takayama

et al. 2005

JOURNAL OF HEALTH SCIENCE

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“…Separations were performed in a polyvinyl-coated capillary at 167C. Chiral CE was applied to stereoselective bioanalysis of amphetamine and analogues together with methadone and its major metabolite in urine, using HP-b-CD as a chiral selector [317].…”

Section: Applications Of Chiral Ce To Biomedical Analysismentioning

confidence: 99%

Recent developments in chiral capillary electrophoresis and applications of this technique to pharmaceutical and biomedical analysis

Ahmad

2001

Electrophoresis

189

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This paper provides an overview of the current status of chiral capillary electrophoresis (CE). The emphasis is placed on the application of CE in chiral separation of various racemic compounds. During the last two years about 280 papers, several review articles, and two entire issues, edited by S. Fanali (Electrophoresis 1999, 20, 2577-2798, and H. Nishi and S. Terabe (J. Chromatogr. A 2000, 879, 1-471.) have been devoted to chiral CE. Enantiomeric separations of various compounds, e.g., pharmaceuticals, drug candidates, drugs and related metabolites in biological fluids, amino acids, di- and tri peptides, pesticides and fungicides, have been performed using different chiral selectors. Native and derivatized cyclodextrins continue to be the most widely used chiral selectors. Other chiral selectors such as natural and synthetic chiral micelles, crown ethers, chiral ligands, proteins, oligo- and polysaccharides, and macrocyclic antibiotics have also been applied to chiral CE separations.

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“…Ramseier et al [98] described confirmation testing of amphetamines and designer drugs in human urine by CZE-ESI-ion trap MS and Geiser et al [99] used NACE-ESI-MS for the simultaneous analysis of some urinary amphetamine derivatives. Furthermore, stereoselective screening and confirmation of urinary enantiomers of amphetamine, methamphetamine, designer drugs and methadone using CZE with 2-hydroxypropyl-b-cyclodextrin as selector was described by Ramseier et al [100]. In that approach, urinary extracts were analyzed at pH 2.5 and having fast-scanning polychrome UV absorption detection.…”

Section: Drugs In Biofluids and Tissuesmentioning

confidence: 99%

Advances of capillary electrophoresis in clinical and forensic analysis (1999-2000)

et al. 2001

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In this paper, capillary electrophoresis in clinical and forensic analysis is reviewed on the basis of the literature of 1999, 2000 and the first papers in 2001. An overview of progress relevant examples for each major field of application, namely (i) analysis of drug seizures, explosives residues, gunshot residues and inks, (ii) monitoring of drugs, endogenous small molecules and ions in biofluids and tissues, (iii) general screening for serum proteins and analysis of specific proteins (carbohydrate deficient transferrin, alpha1-antitrypsin, lipoproteins and hemoglobins) in biological fluids, and (iv) analysis of nucleic acids and oligonucleotides in biological samples, including oligonucleotide therapeutics, are presented.

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Stereoselective screening for and confirmation of urinary enantiomers of amphetamine, methamphetamine, designer drugs, methadone and selected metabolites by capillary electrophoresis

Cited by 57 publications

References 32 publications

Simultaneous Chiral Analysis of Methamphetamine and its Metabolites by Capillary Electrophoresis/Mass Spectrometry with Direct Injection of Urine

Simultaneous Chiral Analysis of Methamphetamine and its Metabolites by Capillary Electrophoresis/Mass Spectrometry with Direct Injection of Urine

Recent developments in chiral capillary electrophoresis and applications of this technique to pharmaceutical and biomedical analysis

Advances of capillary electrophoresis in clinical and forensic analysis (1999-2000)

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