Stereoselective Synthesis of 1,4,2‐Oxazaphosphorines as Precursors of Chiral α‐Aminophosphonic Acids by Intramolecular Heterocyclization of β‐Aldiminoalkylphosphites.

Abstract

Organo-phosphorus compoundsOrgano-phosphorus compounds S 0080 Stereoselective Synthesis of 1,4,2-Oxazaphosphorines as Precursors of Chiral α-Aminophosphonic Acids by Intramolecular Heterocyclization of β-Aldiminoalkylphosphites. -A new route for the stereoselective preparation of α-aminophosphonates based on the reaction of β-aldiminoalcohols with chlorophosphites under mild conditions is developed. -(DIMUKHAMETOV*, M. N.; BAJANDINA, E. V.; DAVYDOVA, E. Y.; LITVINOV, I. A.; GUBAIDULLIN, A. T.; DOBRYNIN, A. B.; ZYABLIKOVA, T. A.; ALFONSOV, V. A.; Heteroat.