Stereoselective synthesis of heterosubstituted aziridines and their functionalization

The Stereoselective Synthesis of Alkenyl‐β‐lactams by Palladium‐Catalyzed [2+2] Carbonylative Cycloaddition

“…Imines were prepared starting from the corresponding carbonyl compounds and amines. [46] The allylic halides 10f, 10i and 10l were prepared starting from commercially available 1-butene, 2-hexene and 1-hexene, respectively, by bromination with N-bromosuccinimide. Petroleum ether refers to the fraction boiling in the range 40Ϫ60°C.…”

Trifluoromethyl aldimines: an overview in the last ten years

“…Based on data reported in the literature for trifluoromethyl aziridines 97 and bidiaziridines, 98 the absolute configuration of the obtained compounds was deduced from 2D-NOESY correlations performed on purified (R,S,S)-140 and (R,R,R)-140'. While no NOE interaction was observed in the minor isomer, a significant NOE interaction between (CH 3 ) 3 −C and H bound to trifluoromethyl substituted carbon was detected in the major isomer, suggesting a 2S,3S absolute configuration for the diaziridine ring of the latter.…”

Synthesis of optically active trifluoromethyl substituted diaziridines and oxaziridines

“…d¼À72.5 (d, 3 d¼0.99 (s, 9H, major), 1.00 (s, 9H, minor), 1.07 (d, 3 J¼6. 9 Hz, 3H, minor), 1.21 (d, 3 J¼6. 4 Hz, 3H, major), 1.87e1.98 (m, 2H), 4.09 (q, 3 J HeF ¼3.…”