Stereoselective Synthesis of Substituted 2-(Z-Styrylsulfonyl)-1H-imidazoles and Benzothiazole

Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy

“…The syntheses of analogues of 3 were modified based on the procedures of Laufer et al 8 Briefly, 4,5-diphenyl-2-thioimidazole was treated with alkyl bromides to give thioethers 10. The thioether was either oxidized to the sulfone 11 first and alkylated 9 or, alternatively, alkylated and then oxidized to yield 13. 10 Deprotonating the benzylic α-carbon and fluorinating once or twice gave analogues 14a and 14b (Scheme 2).…”

ChemInform Abstract: Synthesis of 2,4,6‐Tri‐substituted Pyridine Derivatives in Aqueous Medium via Hantzsch Multi‐Component Reaction Catalyzed by Cerium(IV) Ammonium Nitrate.

“…On the basis of the aforementioned observations and as a part of our research program in the synthesis of novel heterocyclic systems [17][18][19][20][21], we wish to report in this article the modified Hantzsch condensation of 2,4,6-tri-substituted pyridine derivatives catalyzed by CAN via multi-component approach in aqueous medium.…”

Synthesis of 2,4,6-Tri-Substituted Pyridine Derivatives in Aqueous MediumviaHantzsch Multi-Component Reaction Catalyzed by Cerium (IV) Ammonium Nitrate

“…On the basis of the aforementioned observations and as a part of our research program in the synthesis of novel heterocyclic systems , we wish to report in this article the modified Hantzsch condensation of 2,4,6‐tri‐substituted pyridine derivatives catalyzed by CAN via multi‐component approach in aqueous medium.…”