Stereoselective synthesis of Z-3-alkoxy-2-[(4′-methoxyphenyl)methylidene]-1(3H)-isobenzofuranones

Stereochemistry in control of photochemical reactivity: 2,6-Diaryl-4 H -spiro[cyclohexane-1,2′-indene]-1′,3′,4-triones

“…This reaction is reversible and irradiation leads to a photostationary state, although the equilibrium is almost completely shifted toward the phthalides when one or both substituents are aryl groups. 2 Later it was demonstrated that 2-alkyl-2-acyl, 3 2-aryl-2-alkoxy 4 and 2-aryl-2-amino 5 derivatives of 1,3-indandione undergo the same rearrangement.…”

Antioxidant Aryl-Substituted Phthalan Derivatives Produced by Endophytic Fungus Cytospora rhizophorae

“…Polyphenols represent a characteristic family of natural-based organic compounds with strong antioxidant activities ( Dao et al, 2020 ; Bodoira and Maestri, 2020 ). Phthalans featured by a core isobenzofuran skeleton were a typical class of phenols, which have dramatically attracted many medicinal scientists attributable to their affluent structure diversities, novel architecture complexities, and significant pharmaceutical activities in recent years ( Naito and Kaneko, 1969 ; Strobel et al, 2002 ; Harper et al, 2003 ; Kapoor et al, 2003 ; Fotso et al, 2008 ). Especially, the 1-phenyl-phthalan moiety is frequently encountered in numerous natural products and commercially available drugs or drug lead compounds.…”

A new isobenzofuranone derivative from a marine Streptomyces sp.

“…Isobenzofuranones are valuable synthetic intermediates for the syntheses of a variety of ring system compounds [1], which are widely used for antioxidant, antifungal and antibacterial agents [2][3][4][5][6][7][8][9][10]. Therefore, many synthetic strategies have been developed to discover new isobenzofuranones [11][12][13][14][15].…”