Stereoselective synthesis, spectral and antimicrobial studies of some cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones

Pillai, M. Velayutham; Rajeswari, K.; Vidhyasagar, T.

doi:10.1016/j.molstruc.2014.07.050

Cited by 8 publications

(2 citation statements)

References 33 publications

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“…Pillai et al 67 generated a class of novel cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones 57 (Figure 7). The antimicrobial screening showed that a significant growth control of M. Himaelis was achieved by the compound 4 = H) exhibited zones of growth inhibition comparable to that of the positive control.…”

Section: Structures and Activity Of Hydrazide Derivativesmentioning

confidence: 99%

A Comprehensive Investigation of Hydrazide and Its Derived Structures in the Agricultural Fungicidal Field

Chang

Liu

Zhang

et al. 2023

J. Agric. Food Chem.

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Hydrazides are present in many bioactive molecules and exhibit a variety of biological activities, such as insecticidal, herbicidal, antifungal, antitumor, and antiviral effects. In this Review, we review the application of hydrazide and its derived structures in the agricultural fungicidal field, including monohydrazides, diacylhydrazines, hydrazide-hydrazones, and sulfonyl hydrazides. In addition, the antifungal mechanism of action of the hydrazide derivatives was analyzed and summarized, mainly involving succinate dehydrogenase inhibitors, laccase inhibitors, and targeting plasma membranes. Finally, based on the structural analysis of the novel fungicidal lead compounds, the structure−activity relationship of the hydrazide derivatives was constructed and the development trend of hydrazide structures in fungicidal applications was prospected. It is hoped that this Review can provide some significant guidance for the development of new hydrazide fungicides in the future.

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Section: Structures and Activity Of Hydrazide Derivativesmentioning

confidence: 99%

A Comprehensive Investigation of Hydrazide and Its Derived Structures in the Agricultural Fungicidal Field

Chang

Liu

Zhang

et al. 2023

J. Agric. Food Chem.

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“…Structure and antimicrobial activities of compounds 67a-m.Pilai et al have recently described the steroselective synthesis of a series of novel cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones 68a-j demonstrating interesting antibacterial activities against E. aerogenes and some fungal strains (Table26) [62]. …”

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confidence: 99%

Frontiers in Anti-Infective Drug Discovery: Volume 7

2018

Frontiers in Anti-Infective Drug Discovery

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Antimicrobial resistance of Gram-negative bacteria is a major concern and no new classes of antibiotics that are effective against this type of bacteria have been discovered since the 1960s. During the last decades, multiple approaches have been developed to combat such a bacterial resistance. However, the combination of antibiotic resistance mechanisms by bacteria and the limited number of effective antibiotics available, decreases the number of the interventions for the treatment of current bacterial infections. The solution to emerging antibiotic resistance will likely involve new therapies or new classes of antibacterial agents. For a few years now, there was a real interest in the design and synthesis of hydrazones possessing an azometine -NHN=CH-proton and constituting an important class of compounds for new drugs development as anticonvulsants, antidepressants, antitumoral agents. In this context, the design and antimicrobial evaluation of hydrazone derivatives has constituted one of the new strategies developed to fight bacterial resistance. As pointed out the range of biological activities is very broad, and this review will deal exclusively with the synthesis and use of hydrazones as antimicrobial agents and will not cover the other biological properties already well depicted in literature. Thus, we will report herein the scope and limitation of such an approach providing numerous examples demonstrating structure-activity relationships and potent interesting antimicrobial activities against both fungi, Gram-positive and/or Gram-negative bacteria.

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Synthesis, spectroscopic and biological studies of metal complexes of an ONO donor pyrazolylhydrazone – Crystal structure of ligand and Co(II) complex

Ravindran

Minitha²,

Fazil³

et al. 2022

Journal of the Indian Chemical Society

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Stereoselective synthesis, spectral and antimicrobial studies of some cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones

Cited by 8 publications

References 33 publications

A Comprehensive Investigation of Hydrazide and Its Derived Structures in the Agricultural Fungicidal Field

A Comprehensive Investigation of Hydrazide and Its Derived Structures in the Agricultural Fungicidal Field

Frontiers in Anti-Infective Drug Discovery: Volume 7

Synthesis, spectroscopic and biological studies of metal complexes of an ONO donor pyrazolylhydrazone – Crystal structure of ligand and Co(II) complex

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