Stereoselective total synthesis of (−)-pyrenophorol

New antifouling macrodiolides from the deep-sea-derived fungus Trichobotrys effuse DFFSCS021

“…7 These simple macrodiolides possess promising biological activities and unique structures which make them attractive synthetic targets. [8][9][10] While natural 18-membered macrodiolide were few. 1,11 Previous study reported four novel aliphatic phenolic ethers from fungus Trichobotrys effuse.…”

Conformational Analysis, Substituent Effect and Structure Activity Relationships of 16-Membered Macrodiolides

“…The first class consists of 16-membered macrocycles and the second class is a 14-membered macrocycles [9]. QSAR has done much to enhance our understanding of fundamental processes and phenomena in medicinal chemistry and drug design [10][11][12][13][14].…”

Synthesis of amides from imines using Et3SiH/Zn system

“…Various amides are biologically active and show antifungal, antihistamine, anthelmintic and antibacterial properties . Because of their obvious importance, several methods have been described for the synthesis of amides …”