Abstract:Transition‐metal catalyzed asymmetric allylic substitution with alkyl and heteroaryl carbon nucleophiles has been well‐established. However, the asymmetric allylic arylation of acyclic internal alkenes with aryl nucleophiles remains challenging and underdeveloped. Herein we report a stereospecific 3‐aza‐Cope rearrangement interrupted asymmetric allylic substitution‐isomerization (Int‐AASI) that enables asymmetric allylic arylation. By means of this stepwise strategy, both enantioenriched allylic arylation prod… Show more
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