2006
DOI: 10.1161/01.atv.0000201039.21705.dc
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Stereospecific and Redox-Sensitive Increase in Monocyte Adhesion to Endothelial Cells by Homocysteine

Abstract: Objective-Previous studies have shown that elevated homocysteine (Hcy) levels promote the development of atherosclerotic lesions in atherosclerosis-prone animal models. There is evidence that oxidant stress contributes to Hcy's deleterious effects on the vasculature. The accumulation and adhesion of monocytes to the vascular endothelium is a critical event in the development of atherosclerosis. We investigated the effects of Hcy on the interaction between human endothelial cells (EC) (EC line EA.hy 926 and pri… Show more

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Cited by 67 publications
(60 citation statements)
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“…These include decreased bioavailability of nitric oxide [10], altered expression of various thrombotic factors, mitogenic effect on arterial smooth muscle cells [11], and expression of acute stressrelated genes [12]. Moreover, the high pK a of the sulfhydryl group (pK a = 10.0) of Hcys is responsible for the formation of stable disulfide bonds with protein cysteine residues and, in the process, alters or impairs the function of many proteins.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…These include decreased bioavailability of nitric oxide [10], altered expression of various thrombotic factors, mitogenic effect on arterial smooth muscle cells [11], and expression of acute stressrelated genes [12]. Moreover, the high pK a of the sulfhydryl group (pK a = 10.0) of Hcys is responsible for the formation of stable disulfide bonds with protein cysteine residues and, in the process, alters or impairs the function of many proteins.…”
Section: Resultsmentioning
confidence: 99%
“…Clinical feature depends on the site and degree of atherosclerotic changes. The mechanisms by which Hcys damages the blood vessel wall seems to be multifactorial [9][10][11][12][13][14].…”
Section: Introductionmentioning
confidence: 99%
“…[15] Hcys is metabolised into hcysthiolactone that contributes to Hcys toxicity in humans. [16] (Hcys-thiolactone hypothesis)…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, mutual tissue production of strong oxidant peroxynitrite stimulates tyrosine nitration, which leads to protein functional alterations and cellular dysfunction [26]. "uto-oxidation of Hcy metabolites results in H 2 O 2 accumulation and as shown by [ ] and later by [8] prolonged incubation of neurons with Hcy metabolites leads to necrotic cell death.…”
Section: VImentioning
confidence: 99%