Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N,,N’N′-di-S,,S-(2,2′’-dibenzyl)acetic acid. Crystal structure of O,,O′’-dipropyl-ethylenediamine--N,,N′’-di-S,,S-(2,2′’-dibenzyl)acetate dihydrochloride

Antiproliferative, antimigratory, and prooxidative potential of novel platinum( IV ) complexes and resveratrol on breast cancer ( MDA‐MB ‐231) and choriocarcinoma ( JEG ‐3) cell lines

“…Interestingly, time and dose dependence were observed for all investigated compounds, but dependence on chain length was not detected as it was noted previously for platinum complexes with edda (ethylenediamine‐ N , N′ ‐diacetate) ligands by Jurišević et al (2016). Dimitrijević et al (2013) also reported that these compounds were much more potent than cisplatin, by evaluating their cytotoxic capacity on CLL (freshly isolated chronic lymphocytic leukemia cells). Stojković et al (2014) demonstrated high antiproliferative effects of Pt(IV) complexes with some O , O′‐ dialkyl esters of (S , S)‐ ethylenediamine‐ N , N′ ‐ di‐2‐propanoic acid on HCT‐116 and MDA‐MB‐231 cell lines.…”

“…Cisplatin ( cis ‐diammineplatinum(II) dichloride) was purchased from Sigma‐Aldrich, while Res was obtained from Abcam (Cambridge, UK). Pt(IV) complexes used in this study (tetrachlorido( O , O ′‐diethyl‐ethylenediamine‐ N , N ′‐di‐ S , S ‐(2,2′‐dibenzyl) acetate)‐platinum(IV), [PtCl 4 (det‐ S , S ‐eddba)] ( C1 ), tetrachlorido( O , O ′‐dipropyl‐ethylenediamine‐N,N′‐di‐ S , S ‐(2,2′‐dibenzyl) acetate)‐platinum(IV), [PtCl 4 (dpr‐ S , S ‐eddba)] ( C2 ), tetrachlorido( O , O ′‐dibutyl‐ethylenediamine‐N,N′‐di‐ S , S ‐(2,2′‐dibenzyl) acetate)‐platinum(IV), [PtCl 4 (dbu‐ S , S ‐eddba)] ( C3 )), were prepared according to the previously described procedure by Dimitrijević et al (2013) (Scheme 1), where synthesis and characterization (elemental analyses, mass spectra, IR, 1 H and 13 C NMR spectroscopy) of the used Pt(IV) complexes were reported.…”

“…Among others, Pt complexes with diamine ligands are in the field of interest as well. The literature data showed that Pt(II/IV) complexes with edda (ethylenediamine‐ N , N′ ‐diacetate)‐a type of ligands had considerable effects on various cancer cell lines with promising potential to overcome cisplatin‐resistance (Dimitrijević et al, 2013; Jurišević et al, 2016; Petrović et al, 2020; Stojković et al, 2014). Pt(IV) complexes with bidentate N , N′ ‐ligand precursors, O , O ′‐dialkyl esters (alkyl = ethyl, propyl, butyl) of ethylenediamine‐ N , N′ ‐di‐ S , S ‐(2,2′‐dibenzyl) acetic acid (Pt(IV) eddba complexes), used in this study, previously showed extremely stronger antiproliferative potential than cisplatin on freshly isolated chronic lymphocytic leukemia cells (Dimitrijević et al, 2013), but also high toxicity on female rat liver (Paunović et al, 2021).…”

“…Despite previously seen hepatotoxic effects of novel Pt(IV) eddba complexes (Paunović et al, 2021), their promising anticancer potential (Dimitrijević et al, 2013) should be further investigated. Thus, the present study aimed to examine the influence of novel Pt(IV) complexes with certain esters of ethylenediamine‐ N , N′ ‐di‐ S , S ‐(2,2′‐dibenzyl)acetic acid on human breast cancer and choriocarcinoma cell lines in comparison to cisplatin.…”

“…Among others, Pt complexes with diamine ligands are in the field of interest as well. The literature data showed that Pt(II/IV) complexes with edda (ethylenediamine-N,N 0 -diacetate)-a type of ligands had considerable effects on various cancer cell lines with promising potential to overcome cisplatin-resistance (Dimitrijevi c et al, 2013;Juriševi c et al, 2016;Petrovi c et al, 2020;Stojkovi c et al, 2014).…”