Stereotactic Body Radiation Therapy for Early-Stage Breast Cancer Using a Robotic Linear Accelerator-Longer Term Results from a Multi-Institutional Trial

Stereotactic partial breast irradiation in primary breast cancer: A comprehensive review of the current status and future directions

“…Currently, the use of gold fiducials at the level of tumor bed and the evolution of radiation techniques, such as MR-guided RT ( 26 – 28 ), the real-time tracking and respiratory motion control of the CK system ( 46 ) or ExacTrac Adaptive Gating System (Novalis ® ) ( 38 , 47 , 48 ), and some new breast devices ( 49 – 51 ), have also heightened the interest in the use of SPBI in the adjuvant setting, reducing radiation delivery uncertainty related to the pliability and mobility of the breast tissue and a more accurate dose distribution, limiting the dose at OARs.…”

Stereotactic Partial Breast Irradiation

“…Thus, stereotactic partial breast irradiation (SPBI) has inspired novel delivery methods, including Cyberknife(Accuray), Gammapod (Xcision), and heavy ion therapy. [23][24][25] In seminal dose-finding studies, dose escalation with SPBI was achieved with acceptable tumor control and cosmetic outcomes (Table 1). [26][27][28][29][30][31][32][33][34] Doses up to 40 Gy in 5 fractions and 30 Gy in a single fraction were achieved without significant acute or late toxicity, unlike the accelerated hypofractionated WBRT experience from UK FAST-Forward.…”

“…As a result of improved precision of radiation delivery to submillimeter levels by incorporating stereotactic localization and advanced image guidance, ablative doses of radiation can be achieved. Thus, stereotactic partial breast irradiation (SPBI) has inspired novel delivery methods, including Cyberknife(Accuray), Gammapod(Xcision), and heavy ion therapy 23–25. In seminal dose-finding studies, dose escalation with SPBI was achieved with acceptable tumor control and cosmetic outcomes (Table 1).…”