“…Our results and those of Woody et al 8 are similar to another published report on NSCLC > 3 cm. 9 Tumor histology (adenocarcinoma vs. squamous), location (peripheral vs. central), largest tumor dimension, and PTV all did not have any predictive value in identifying distant control. With only 2 subjects identified as having local failure, few conclusions can be drawn regarding risk factors for local failure.…”
Section: Discussionmentioning
confidence: 83%
“…Woody et al 8 reported on 40 patients with nonoperable NSCLC > 5 cm, and several series examined subsets of NSCLC > 3 cm. 7,9 Larger tumors have been associated with more nonlocal failures and worse survival rates. 10,11 Because of the paucity of the data and the existing need for research in this field, we analyzed our prospective SBRT database of NSCLC tumors > 5 cm.…”
SBRT for tumors > 5 cm is effective, with good local control rates and acceptable toxicity. The main pattern of failure is distant, suggesting a possible role for systemic chemotherapy in these patients.
“…Our results and those of Woody et al 8 are similar to another published report on NSCLC > 3 cm. 9 Tumor histology (adenocarcinoma vs. squamous), location (peripheral vs. central), largest tumor dimension, and PTV all did not have any predictive value in identifying distant control. With only 2 subjects identified as having local failure, few conclusions can be drawn regarding risk factors for local failure.…”
Section: Discussionmentioning
confidence: 83%
“…Woody et al 8 reported on 40 patients with nonoperable NSCLC > 5 cm, and several series examined subsets of NSCLC > 3 cm. 7,9 Larger tumors have been associated with more nonlocal failures and worse survival rates. 10,11 Because of the paucity of the data and the existing need for research in this field, we analyzed our prospective SBRT database of NSCLC tumors > 5 cm.…”
SBRT for tumors > 5 cm is effective, with good local control rates and acceptable toxicity. The main pattern of failure is distant, suggesting a possible role for systemic chemotherapy in these patients.
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