Stereotactic Body Radiation Therapy in Centrally and Superiorly Located Stage I or Isolated Recurrent Non–Small-Cell Lung Cancer

Chang, Joe Y.; Balter, Peter A; Dong, Lei; Yang, Qiuan; Liao, Zhongxing; Jeter, Melenda; Bucci, M. Kara; McAleer, Mary Frances; Mehran, Reza J.; Roth, Jack A.; Komaki, Ritsuko

doi:10.1016/j.ijrobp.2008.08.001

Cited by 230 publications

(172 citation statements)

References 9 publications

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“…The esophageal dose constraints in this study required that the maximum dose to 1 mL of esophagus be B35 Gy (8.8 Gy/fx) and that the maximum dose to 10 mL be B30 Gy (7.5 Gy/fx). Using these constraints, there were no cases of esophagitis observed [20]. Moreover, in a phase II trial of SBRT (50 Gy in 10 fractions) for oligometastatic disease, Milano and colleagues treated thoracic lymph nodes, including mediastinal nodes, in 24 patients and observed no cases of grade 3 esophagitis [21].…”

Section: Discussionmentioning

confidence: 99%

Is there a role for consolidative stereotactic body radiation therapy following first-line systemic therapy for metastatic lung cancer? A patterns-of-failure analysis

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Is there a role for consolidative stereotactic body radiation therapy following first-line systemic therapy for metastatic lung cancer? A patterns-of-failure analysis

et al. 2009

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“…Patient immobilisation is important for conventionally fractionated radiotherapy and stereotactic body radiotherapy (SBRT) 1, 2, 3, 4, 5, 6. The risk of a geographical miss or positioning error for hypo‐fractionated techniques can be greater than with conventional fractionation 1, 7, 8, 9, 10, 11, 12, 13.…”

Section: Introductionmentioning

confidence: 99%

A randomised comparison of three different immobilisation devices for thoracic and abdominal cancers

et al. 2016

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IntroductionPatient immobilisation is critically important for both highly conformal conventionally fractionated radiotherapy and for stereotactic body radiotherapy. Different immobilisation devices are available to maintain patient position for radiotherapy but the most suitable one remains unknown.MethodsForty‐five patients were randomly allocated to one of three immobilisation devices; the Q fix arm shuttle, BodyFIX without wrap or BodyFIX with wrap. Patients were imaged before and after treatment to ascertain intra‐fraction and inter‐fraction motion. Bony anatomy was used for matching to determine the positional accuracy of each device. Treatments were timed using a standard method. Patient comfort and staff satisfaction questionnaires were also issued to determine comfort, ease of use and preferences for each device.ResultsThe BodyFIX without wrap was the more accurate device; however, the differences between the devices were not statistically significant. The BodyFIX with wrap was found to take significantly longer to set up and set down compared to the arm shuttle and the BodyFIX without wrap (all P < 0.001). Patients (37%) marginally preferred the BodyFIX with wrap. Most (81%) staff preferred the BodyFIX without wrap.ConclusionImmobilisation using the BodyFIX without wrap was deemed to be suitable for clinical use. It was a clinically accurate device, the more efficient in terms of set up and set down time, the most preferred by staff and was accepted by patients.

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“…Promising early stereotactic radiosurgery clinical experiences have driven clinical trial investigation of ablative radiation for treatment of lung cancers 25,26 . Experience has led investigators to use ablative radiation against a variety of tumor types metastasizing to the lung 27,28 .…”

Section: Discussionmentioning

confidence: 99%

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Kunos

Fabien

Shanahan

et al. 2015

JoVE

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Physicians considering stereotactic ablative body radiation therapy (SBRT) for the treatment of extracranial cancer targets must be aware of the sizeable risks for normal tissue injury and the hazards of physical tumor miss. A first-of-its-kind SBRT platform achieves high-precision ablative radiation treatment through a combination of versatile real-time imaging solutions and sophisticated tumor tracking capabilities. It uses dualdiagnostic kV x-ray units for stereoscopic open-loop feedback of cancer target intrafraction movement occurring as a consequence of respiratory motions and heartbeat. Image-guided feedback drives a gimbaled radiation accelerator (maximum 15 x 15 cm field size) capable of real-time ±4 cm pan-and-tilt action. Robot-driven ±60° pivots of an integrated ±185° rotational gantry allow for coplanar and non-coplanar accelerator beam set-up angles, ultimately permitting unique treatment degrees of freedom. State-of-the-art software aids real-time six dimensional positioning, ensuring irradiation of cancer targets with sub-millimeter accuracy (0.4 mm at isocenter). Use of these features enables treating physicians to steer radiation dose to cancer tumor targets while simultaneously reducing radiation dose to normal tissues. By adding respiration correlated computed tomography (CT) and 2-[ . In this article, we describe new radiation plans for the treatment of moving lung tumors.

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Stereotactic Body Radiation Therapy in Centrally and Superiorly Located Stage I or Isolated Recurrent Non–Small-Cell Lung Cancer

Cited by 230 publications

References 9 publications

Is there a role for consolidative stereotactic body radiation therapy following first-line systemic therapy for metastatic lung cancer? A patterns-of-failure analysis

Is there a role for consolidative stereotactic body radiation therapy following first-line systemic therapy for metastatic lung cancer? A patterns-of-failure analysis

A randomised comparison of three different immobilisation devices for thoracic and abdominal cancers

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

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