Stereotactic fine-needle aspiration cytology of nonpalpable breast lesions: An analysis of 258 consecutive aspirates

Sarfati, Mark R.; Fox, Kenneth A.; Warneke, James; Fajardo, Laurie L.; Hunter, Glenn C.; Rappaport, William D.

doi:10.1016/s0002-9610(05)80116-3

Cited by 19 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These include ultrasound-guided fine-needle aspiration (FNA) or core-needle biopsy, 2 stereotactic FNA 3 or stereotactic core-needle biopsy (SC bx), 4 -6 stereotactic suction-assisted large core-needle biopsy (Mammotome [Mbx]), 7 stereotactic coring excisional biopsy (Advanced Breast Biopsy Instrument [ABBI]), 8,9 and open WL bx. 10 Ultrasound-guided biopsy is useful only if the lesion can be seen sonographically; therefore, microcalcifications cannot be sampled using this technique.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Mammographically Guided Breast Biopsy Techniques

et al. 1999

View full text Add to dashboard Cite

ObjectiveTo determine which mammographically guided breast biopsy technique is the most efficient in making a diagnosis in women with suspicious mammograms. Summary Background DataMammographically guided biopsy techniques include stereotactic 14-gauge core-needle biopsy (SC bx), stereotactic 11-gauge suction-assisted core biopsy (Mammotome [Mbx]), stereotactic coring excisional biopsy (Advanced Breast Biopsy Instrument [ABBI]), and wirelocalized biopsy (WL bx). Controversy exists over which technique is best. MethodsAll patients undergoing any one of these biopsy methods over a 15-month period were reviewed, totaling 245 SC bx, 107 Mbx, 104 ABBI, and 520 WL bx. Information obtained included technical success, pathology, discordant pathology, and need for open biopsy. ResultsTechnical success was achieved in 94.3% of SC bx, 96.4% of Mbx, 92.5% of ABBI, and 98.7% of WL bx. The sensitivity and specificity were 87.5% and 98.6% for SC bx, 87.5% and 100% for Mbx, and 100% and 100% for ABBI. Discordant results or need for a repeat biopsy occurred in 25.7% of SC bx, 23.2% of Mbx, and 7.5% of ABBI biopsies. In 63.6% of ABBI and 50.9% of WL bx, positive margins required reexcision; of the cases with positive margins, 71.4% of ABBI and 70.4% of WL bx had residual tumor in the definitive treatment specimen. ConclusionAlthough sensitivities and specificities of SC bx and Mbx are good, 20% to 25% of patients will require an open biopsy because a definitive diagnosis could not be reached. This does not occur with the ABBI excisional biopsy specimen. The positive margin rates and residual tumor rates are comparable between the ABBI and WL bx. The ABBI avoids operating room and reexcision costs; therefore, in appropriately selected patients, this appears to be the most efficient method of biopsy.Screening mammography has led not only to early detection of breast cancers, but also to an increase in the number of abnormal mammograms requiring evaluation. With present technology, abnormal mammograms can be dealt with in one of two basic ways: observation or biopsy. An evaluation of management options using a decision analysis model demonstrated that for a typical 50-year-old woman, quality adjusted life expectancy is maximized by early wire-localized biopsy (WL bx) when the risk of malignancy exceeds 30%.

show abstract

Section: Resultsmentioning

confidence: 99%

Comparison of Mammographically Guided Breast Biopsy Techniques

et al. 1999

View full text Add to dashboard Cite

show abstract

“…2 FNA cytology is a valuable tool in distinguishing benign from malignant nodules and has contributed greatly to reducing the rate of unnecessary surgery. 3 Although FNA cytology gained acceptance in the diagnosis of breast lesions, 4,5 there are some limitations: false negative and false positive diagnoses. Inaccurate diagnoses are related to specimen adequacy, the physician's skill in performing the aspiration, the pathologist's experience in interpreting the aspirate and the overlapping cytologic features between benign and malignant lesions.…”

Section: Objective: To Evaluate the Accuracy Of Fine Needle Aspiratiomentioning

confidence: 99%

Analysis of Fine Needle Aspiration Cytology of the Breast

Choi¹,

Choi²,

Lee³

et al. 2004

Acta Cytologica

View full text Add to dashboard Cite

“…Nonpalpable cancer is one of most dif®cult to lead to accurate diagnosis. Not only the detection but diagnostic technique has yet be clearly de®ned and still on dispute [11,12,14,15].…”

Section: Discussionmentioning

confidence: 99%

Statistical analysis of diagnostic failure of fine needle aspiration cytology (FNAC) in breast cancer

Shoji¹,

Tominaga²,

Nakagawa³

et al. 2001

J. Surg. Oncol.

View full text Add to dashboard Cite

Fine-needle aspiration cytology (FNAC) was performed on 300 patients. Among those, 57 cases failed in accurate diagnosis of malignancy and 243 were successful. Fourteen clinicopathological factors altogether were analyzed to elucidate any correlation with FNAC failure using uni- and multivariate analysis. The univariate analysis in each clinicopathlogical factor showed that these error cases were vaguely palpable cancers, estrogen receptor (ER) positive cancers, small-sized of tumors, scattered type of cancer cell distribution in tumor tissues, with low tumor grade, with low Nottingham prognostic index (NPI), with benign-like ultrasound findings and with low TNM stage. The multivariate analysis revealed tumor grade was the strongest factor for all, followed by cellular distribution type of cancer cells and benign-like ultrasound findings. From these results, we speculated that diagnostic failure of FNAC at first clinic visit seemed to be caused by mainly two histocytological factors: extrinsic factor (structural factors of tissue-like tumor cells' distribution pattern, etc.); and intrinsic one (cellular factors of low atypism such as benign-like ultrasound finding, low tumor grade, and so on).

show abstract

Stereotactic fine-needle aspiration cytology of nonpalpable breast lesions: An analysis of 258 consecutive aspirates

Cited by 19 publications

References 15 publications

Comparison of Mammographically Guided Breast Biopsy Techniques

Comparison of Mammographically Guided Breast Biopsy Techniques

Analysis of Fine Needle Aspiration Cytology of the Breast

Statistical analysis of diagnostic failure of fine needle aspiration cytology (FNAC) in breast cancer

Contact Info

Product

Resources

About