2003
DOI: 10.3171/foc.2003.14.5.13
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Stereotactic radiosurgery for hypersecreting pituitary tumors: part of a multimodality approach

Abstract: Object Surgical and medical therapies successfully achieve biochemical remission in the majority of patients with secretory pituitary adenomas. Nevertheless, continued hypersecretion after first-line therapy occurs and requires adjunctive therapy to prevent morbidity and premature mortality. For patients in whom medical and surgical therapy have failed, gamma knife surgery (GKS) is performed with the goal of controlling tumor growth and excess growth hormone (GH) pro… Show more

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Cited by 68 publications
(25 citation statements)
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“…In fact, of the studies in our analysis in which a normal IGF-I level was the only criterion for hor-monal cure, the rates of endocrinological remission ranged from 20% to 71%. 18,20,36,48,60 As hormonal remission rates following radiosurgery were noted in 17% to 82% of patients in studies in which the more stringent criteria were applied, 2,4,5,14,16,21,33,[45][46][47]53,54,57,58 it appears that the definition of endocrinological remission is of variable consequence.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, of the studies in our analysis in which a normal IGF-I level was the only criterion for hor-monal cure, the rates of endocrinological remission ranged from 20% to 71%. 18,20,36,48,60 As hormonal remission rates following radiosurgery were noted in 17% to 82% of patients in studies in which the more stringent criteria were applied, 2,4,5,14,16,21,33,[45][46][47]53,54,57,58 it appears that the definition of endocrinological remission is of variable consequence.…”
Section: Discussionmentioning
confidence: 99%
“…Although one study of Nelson's syndrome patients showed no tumour re-growth at 7 years post GKS therapy (82), a further study showed remission rates post GKS to be only 14% (83). GKS seems to be most effective in Nelson's syndrome when it is administered soon after TBA (82) and when the anatomical target is clear and discrete (less likely with prior surgery, which may render the tumour border indistinct (78,81)).…”
Section: Stereotactic Radiosurgerymentioning
confidence: 99%
“…Several groups have reported a low incidence (0-36%) of pituitary dysfunction following radiosurgery (Jagannathan et al, 2007;Jane et al, 2003;Sheehan et al, 2006;Pollock et al, 1994). This incidence is likely higher when patients are followed longterm, with the Karolinska Institute reporting a 72% incidence of hypopituitarism when patients were followed over 10 years (Hoybye et al, 2001).…”
Section: Complications Following Radiosurgery For Pituitary Adenomasmentioning
confidence: 99%