Stereotactic radiosurgery for patients with nonsmall cell lung carcinoma metastatic to the brain

Kim, Young Soo; M.D., F.R.C.S. Douglas Kondziolka; Flickinger, John C.; Lunsford, L. Dade

doi:10.1002/(sici)1097-0142(19971201)80:11<2075::aid-cncr6>3.0.co;2-w

Cited by 117 publications

(54 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kim et al (1997) reported on 77 patients with 115 metastases from non-small-cell lung cancer. Seventy-one patients also received whole brain radiation therapy (mean dose, 34 Gy; range, 15±56 Gy).…”

Section: Resultsmentioning

confidence: 99%

“…To do so, reports containing information on the in¯uence of``activity of extracranial disease'' on overall survival were identi®ed in the English language literature using computer and manual search. During the search, it was recognised that while the majority of reports use this particular term (Alexander et al 1995;Auchter et al 1996;Engenhart et al 1993;Joseph et al 1996;Kim et al 1997;Mori et al 1998;Shiau et al 1997), others use similar terms, such as``extracranial disease'' or``extracranial tumour'' (Breneman et al 1997;Kocher et al 1998, Pirzkall et al 1998Shu et al 1996;Cho et al 1998) which may imply the addition of the activity of uncontrolled primary tumour, too. Whatever is meant by the latter two terms, for the purpose of this review it is assumed that the substantial part of that in¯uence is coming from wide-spread distant metastases, which would be equal to the term``extracranial metastases''.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Activity of extracranial metastases as a prognostic factor influencing survival after radiosurgery of brain metastases

Jeremić¹,

Becker²,

Plaßwilm³

et al. 2000

Journal of Cancer Research and Clinical Oncology

View full text Add to dashboard Cite

Information about prognostic factors influencing survival have been only occasionally reported in studies on the use of radiosurgery in the treatment of patients with brain metastasis. To answer the question of whether activity of extracranial metastases is an independent prognostic factor influencing survival in radiosurgery of brain metastases, a review of the literature was performed. Fourteen studies were identified in the English language literature that dealt with this topic. Only three studies showed borderline insignificance of the influence of activity of extracranial metastases when analysed by univariate methods. When multivariate analysis was used to test for the independent influence of this factor on survival, of nine studies that used that statistical approach eight showed that it is an independent prognosticator influencing survival, most often being the strongest one. This review of literature supports the view that the "activity of extracranial metastases" is an independent prognostic factor influencing survival of these patients as documented in published reports. However, prospective randomised trials are necessary to definitely establish the independent influence of this prognostic factor.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Activity of extracranial metastases as a prognostic factor influencing survival after radiosurgery of brain metastases

Jeremić¹,

Becker²,

Plaßwilm³

et al. 2000

Journal of Cancer Research and Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…This median survival was less impressive than that achieved by the group who underwent SRS for BM from other primary cancers (lung, 10 months; renal cell, 11 months; breast, 13 months; melanoma, 7 months). [32][33][34][35] The local control rate was 84% and there were few side effects. However, the patients in that study who had active extracranial disease had a median survival of only 2 months after SRS.…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary management of colorectal brain metastases

Kruser

Chao

Elson

et al. 2008

Cancer

View full text Add to dashboard Cite

BACKGROUND.The incidence of brain metastases (BM) from colorectal cancer (CRC) is increasing, and the management of this previously rare complication at a single institution is reported.METHODS.The records of all patients with BM from 1994 to 2005 were reviewed, and 49 patients (33 men, 16 women) with 102 BM from CRC were identified. Associations between patient and tumor characteristics, treatment modality, and survival were assessed.RESULTS.The median age at diagnosis of BM from CRC was 66 years. Forty patients (82%) had other systemic disease. The median survival after a diagnosis of BM from CRC was 5.1 months. Fifteen patients (31%) underwent surgery at some point, 14 patients (29%) underwent stereotactic radiosurgery (SRS), and 42 patients (86%) received whole‐brain radiotherapy during their management. Seven patients (14%) underwent upfront SRS. On multivariate analysis, a longer interval from diagnosis of CRC to diagnosis of BM was associated significantly with shorter survival (p = .01). Sex, Karnofsky performance status, tumor location, recursive partitioning analysis class, and initial treatment modality did not have an impact on survival.CONCLUSIONS.Because BM from CRC are a late‐stage phenomenon, the majority of patients in the current study had other systemic involvement, and survival after CNS involvement was poor. The results indicated that a high prevalence of systemic disease limits the proportion of patients who are strong candidates for upfront SRS, thereby limiting the impact that this modality has on outcomes in this population as a whole. Late development (>1 year after the primary tumor diagnosis) of CNS involvement may predict for poorer survival after therapy for patients with BM from CRC. Cancer 2008. © 2008 American Cancer Society.

show abstract

“…However, it is indisputable that accurate identifi cation of cerebral metastases is important for staging or restaging, predicting prognosis, and determining appropriate therapy [1][2][3].…”

mentioning

confidence: 94%

Accuracy of whole-body FDG-PET/CT for detecting brain metastases from non-central nervous system tumors

et al. 2008

View full text Add to dashboard Cite

show abstract

Stereotactic radiosurgery for patients with nonsmall cell lung carcinoma metastatic to the brain

Abstract: Stereotactic radiosurgery for NSCLC brain metastases is effective and is associated with few complications. The early detection of brain metastases and treatment with radiosurgery combined with radiation therapy provide the opportunity for extended high quality survival.

Cited by 117 publications

References 45 publications

Activity of extracranial metastases as a prognostic factor influencing survival after radiosurgery of brain metastases

Activity of extracranial metastases as a prognostic factor influencing survival after radiosurgery of brain metastases

Multidisciplinary management of colorectal brain metastases

Accuracy of whole-body FDG-PET/CT for detecting brain metastases from non-central nervous system tumors

Contact Info

Product

Resources

About