Stereotactic radiosurgery for the treatment of brain metastases

A Comprehensive Review of MR Imaging Changes following Radiosurgery to 500 Brain Metastases

“…[2][3][4][5] The average survival of patients with SRS-treated brain metastases is 6 -8 months. Within this timeframe, studies have shown SRS to achieve a 90% radiographic lesional control rate, defined as lesions with stable or decreasing size.…”

A Comparison of Radiotherapy with Radiotherapy plus Surgery for Brain Metastases from Urinary Bladder Cancer

“…Therefore, SRS represents a valuable alternative choice in certain patients [25,35] characterized by a high LC response rate and low morbidity, as in our present work. Previous analyses have demonstrated a clear LC and, in some cases, OS benefit for SRS in patients with a limited number of brain metastases [2,23,25,[28][29][30]. Whether SRS would demonstrate a survival advantage if only applied in TCC patients with few brain secondaries (up to three) in our institute, remains a speculation and a higher number of patients are required to clarify this issue.…”

“…OS rates between RT (WBRT and/or SRS) and RT + OP were not statistically different, indicating the potential of SRS in treatment of brain lesions. The advent of new chemotherapy agents and the implementation of SRS in the treatment of brain metastases have stressed the importance of identifying prognostic factor [4,23,25,27,29]. In TCC patients with cerebral secondaries, however, and to the authors' best knowledge, no data exist regarding this issue, probably due to the small number of patients previously studied (Table 1).…”

“…Several groups have indicated that stereotactic radiosurgery (SRS) can be a useful alternative approach for the treatment of patients with brain metastases, with local control (LC) and overall survival (OS) rates comparable to those of surgery (OP), in certain cases [4,5,25,29]. In TCC patients with cerebral lesions, the role of SRS remains unknown.…”

The History of Stereotactic Radiosurgery Development and Its Role in the Treatment of Brain Metastases

“…У большинства этих пациентов смерть наступает по неврологическим причинам, а не из-за системного прогрессирования заболевания [3]. Несмотря на разработку новых терапевтических подходов, прогноз пациентов с метастазами в головной мозг остается неутешительным [6]. Лечение таких больных должно быть индивидуализированным с за-действованием междисциплинарной команды.…”