Stereotactic radiosurgery for treatment of osteosarcomas involving the distal portions of the limbs in dogs

Farese, James P.; Milner, Rowan J.; Thompson, Margaret Susan; Lester, Nola V.; Cooke, Kristen; Fox, Leslie E.; Hester, Juli; Bova, Francis J.

doi:10.2460/javma.2004.225.1567

Cited by 80 publications

(94 citation statements)

References 30 publications

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“…12,15 Alternatively, a wide variety of limb-sparing surgical techniques have been described. 12,15–20 Additionally, radiation therapy in the form of stereotactic radiosurgery has been attempted with curative intent, 14 and palliative radiation therapy has been found to be effective in decreasing pain and inflammation in up to 92% of cases. 21 Multiple studies 1,2,12,22,23 have reported that adjuvant chemotherapy may prolong survival times in dogs with osteosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of outcome and prognostic factors for dogs living greater than one year after diagnosis of osteosarcoma: 90 cases (1997–2008)

Culp¹,

Olea‐Popelka²,

Sefton³

et al. 2014

javma

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Objective To evaluate clinical characteristics, outcome, and prognostic variables in a cohort of dogs surviving > 1 year after an initial diagnosis of osteosarcoma. Design Retrospective case series. Animals 90 client-owned dogs. Procedures Medical records for an 11-year period from 1997 through 2008 were reviewed, and patients with appendicular osteosarcoma that lived > 1 year after initial histopathologic diagnosis were studied. Variables including signalment, weight, serum alkaline phosphatase activity, tumor location, surgery, and adjuvant therapies were recorded. Median survival times were calculated by means of a Kaplan-Meier survival function. Univariate analysis was conducted to compare the survival function for categorical variables, and the Cox proportional hazard model was used to evaluate the likelihood of death > 1 year after diagnosis on the basis of the selected risk factors. Results 90 dogs met the inclusion criteria; clinical laboratory information was not available in all cases. Median age was 8.2 years (range, 2.7 to 13.3 years), and median weight was 38 kg (83.6 lb; range, 21 to 80 kg [46.2 to 176 lb]). Serum alkaline phosphatase activity was high in 29 of 60 (48%) dogs. The most common tumor location was the distal portion of the radius (54/90 [60%]). Eighty-nine of 90 (99%) dogs underwent surgery, and 78 (87%) received chemotherapy. Overall, 49 of 90 (54%) dogs developed metastatic disease. The median survival time beyond 1 year was 243 days (range, 1 to 1,899 days). Dogs that developed a surgical-site infection after limb-sparing surgery had a significantly improved prognosis > 1 year after osteosarcoma diagnosis, compared with dogs that did not develop infections. Conclusions and Clinical Relevance Results of the present study indicated that dogs with an initial diagnosis of osteosarcoma that lived > 1 year had a median survival time beyond the initial year of approximately 8 months. As reported previously, the development of a surgical-site infection in dogs undergoing a limb-sparing surgery significantly affected prognosis and warrants further study.

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Section: Discussionmentioning

confidence: 99%

Evaluation of outcome and prognostic factors for dogs living greater than one year after diagnosis of osteosarcoma: 90 cases (1997–2008)

Culp¹,

Olea‐Popelka²,

Sefton³

et al. 2014

javma

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show abstract

“…In general terms, radiation therapy can be given with palliative or curative intent. Curative‐intent radiation is delivered as stereotactic radiation therapy (SRT) for OSA . Compared with SRT, palliative radiation therapy delivers a lower total dose or the total dose is delivered less intensively (weekly vs daily) .…”

Section: Discussionmentioning

confidence: 99%

Limb‐sparing in dogs using patient‐specific, three‐dimensional‐printed endoprosthesis for distal radial osteosarcoma: A pilot study

Séguin¹,

Pinard²,

Lussier

et al. 2019

Vet Comparative Oncology

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Limb‐sparing for distal radial osteosarcoma has a high rate of complications. Using personalized three‐dimensional (3D)‐printed implants might improve outcome. The goals of this study were to optimize use of patient‐specific, 3D‐printed endoprostheses for limb‐sparing in dogs in the clinical environment and to report the outcome. This was a pilot study where five client‐owned dogs were enrolled. Computed tomography (CT) of the thoracic limbs was performed, which was used to create patient‐specific endoprostheses and cutting guides, and repeated on the day of surgery. Intra‐arterial (IA) carboplatin was introduced in the clinical management. Limb‐sparing was performed. Outcome measures were time required to produce the endoprosthesis and cutting guide, fit between cutting guide and endoprosthesis with host bones, gait analysis, size of the tumour, percent tumour necrosis, complications, disease‐free interval (DFI) and survival time (ST). Four dogs received IA carboplatin. Excessive tumour growth between planning CT and surgery did not occur in any dog. The interval between the CT and surgery ranged from 14 to 70 days. Fit between the cutting‐guide and endoprosthesis with the host bones was good to excellent. At least one complication occurred in all dogs. Two dogs were euthanized with STs of 192 and 531 days. The other dogs were alive with a follow up of 534 to 575 days. IA chemotherapy is a promising strategy to minimize the risk of excessive tumour growth while waiting for the endoprosthesis and cutting‐guide to be made. The design of the cutting‐guide was critical for best fit of the endoprosthesis with host bones.

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“…However, complications associated with these procedures are common, including infection (in up to 78% of cases), tumor recurrence (rates as high as 24%), and construct failure (in up to 40% of cases). Limb salvage by curative intent radiation therapy for local tumor control has been described using full‐course fractionated therapy, intraoperative extracorporeal radiation therapy, and stereotactic radiosurgery, but resulted in pathologic fractures in up to 60% of cases . Dogs undergoing palliative medical care for appendicular OSA have recently been reported to sustain pathologic fractures in 38% of cases, with a median time from diagnosis to euthanasia or death of 111 days .…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties of canine osteosarcoma‐affected antebrachia

et al. 2017

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OSA of the distal radial metaphysis in dogs presented for limb amputation markedly compromises the structural integrity of affected antebrachia. However, biomechanical properties of affected bones was sufficient for weight-bearing, as none of the neoplastic antebrachia fractured before amputation. The behavior of tumor invaded bone under cyclic loading warrants further investigations to evaluate the viability of in situ therapies for bone tumors in dogs.

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Stereotactic radiosurgery for treatment of osteosarcomas involving the distal portions of the limbs in dogs

Cited by 80 publications

References 30 publications

Evaluation of outcome and prognostic factors for dogs living greater than one year after diagnosis of osteosarcoma: 90 cases (1997–2008)

Evaluation of outcome and prognostic factors for dogs living greater than one year after diagnosis of osteosarcoma: 90 cases (1997–2008)

Limb‐sparing in dogs using patient‐specific, three‐dimensional‐printed endoprosthesis for distal radial osteosarcoma: A pilot study

Mechanical properties of canine osteosarcoma‐affected antebrachia

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