Stereotactic Radiosurgical Treatment of Brain Metastases to the Choroid Plexus

Siomin, Vitaly; Lin, Jennifer L.; Marko, Nicholas F.; Barnett, Gene H.; Toms, Steven; Chao, Samuel T.; Angelov, Lilyana; Vogelbaum, Michael A.; Navaratne, Kapila; Suh, John H.; Weil, Robert J.

doi:10.1016/j.ijrobp.2010.03.016

Cited by 18 publications

(15 citation statements)

References 47 publications

(107 reference statements)

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“…Brain metastases of extracranial malignancies are not restricted to parenchymal lesions. Metastases within the choroid plexus or the ventricles as well as leptomeningeal tumor spread have been described both in neuroblastoma [ 4 ] and various other malignancies in children and adults [ 23 – 25 ]. In these patients, the choroid plexus might have been an entry site of tumor cells to the CNS [ 23 ], with circulating cancer cells migrating from the lumen of the fenestrated choroidal capillaries to that of ventricles.…”

Section: Discussionmentioning

confidence: 99%

The choroid plexus may be an underestimated site of tumor invasion to the brain: an in vitro study using neuroblastoma cell lines

et al. 2015

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BackgroundThe central nervous system (CNS) is protected by several barriers, including the blood–brain (BBB) and blood-cerebrospinal fluid (BCSFB) barriers. Understanding how cancer cells circumvent these protective barriers to invade the CNS is of crucial interest, since brain metastasis during cancer is often a fatal event in both children and adults. However, whereas much effort has been invested in elucidating the process of tumor cell transmigration across the BBB, the role of the BCSFB might still be underestimated considering the significant number of meningeal cancer involvement. Our work aimed to investigate the transmigration of neuroblastoma cells across the BCSFB in vitro.MethodsWe used an inverted model of the human BCSFB presenting proper restrictive features including adequate expression of tight-junction proteins, low permeability to integrity markers, and high trans-epithelial electrical resistance. Two different human neuroblastoma cell lines (SH-SY5Y and IMR-32) were used to study the transmigration process by fluorescent microscopy analysis.ResultsThe results show that neuroblastoma cells are able to actively cross the tight human in vitro BCSFB model within 24 h. The presence and transmigration of neuroblastoma cancer cells did not affect the barrier integrity within the duration of the experiment.ConclusionsIn conclusion, we presume that the choroid plexus might be an underestimated site of CNS invasion, since neuroblastoma cell lines are able to actively cross a choroid plexus epithelial cell layer. Further studies are warranted to elucidate the molecular mechanisms of tumor cell transmigration in vitro and in vivo.Electronic supplementary materialThe online version of this article (doi:10.1186/s12935-015-0257-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

The choroid plexus may be an underestimated site of tumor invasion to the brain: an in vitro study using neuroblastoma cell lines

et al. 2015

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“…A few previous reports have shown that surgical management of CPM originating from thyroid cancer results in better outcomes (11,12). In addition, Siomin et al reported that SRT presents a safe and viable primary treatment option for CPM of RCC, non-small cell lung cancer and esophageal cancer, with a survival time after SRT of 25.3±23.4 months (39). In the present case, the tumor was of small size and SRT was chosen as a less invasive treatment.…”

Section: Discussionmentioning

confidence: 62%

Choroid Plexus Metastasis of Follicular Thyroid Carcinoma Diagnosed due to Intraventricular Hemorrhage

et al. 2015

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Choroid plexus metastasis (CPM) is extremely rare and originates most frequently from renal cell carcinoma (RCC). We herein report the case of a 58-year-old man who developed a solitary CPM lesion derived from follicular thyroid carcinoma in addition to intraventricular hemorrhage. Computed tomography revealed acute hydrocephalus as a result of the hemorrhage, and we planned endoscopic hematoma evacuation. Since it was too difficult to reach the hematoma, we considered the possibility of a neoplasm and performed a biopsy of the lesion, the results of which led to an accurate diagnosis of CPM in this case. We also review previous reports of CPM originating from thyroid carcinoma compared with RCC.

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“…[ 8 ] Although microsurgical resection has been successfully adopted for most solitary metastasis in patients with a good clinical course, growing evidence suggests that SRS is associated with a median overall survival of 2 years (4–12 months with open surgical resection), an approximate 96% tumor control rate (compared with 79% for surgical resection), and a faster postoperative recovery. [ 3 , 8 , 22 , 24 ] Although open craniotomy with gross-total resection presents higher morbidity and mortality rates compared with SRS,[ 3 ] the latter should only be considered in case of intraventricular metastasis not exceeding 4 cm in diameter. [ 8 ] As for the present case, SRS did not represent the treatment of choice since the diameter of the lesion and the overall general status of the patient allowed for a gross-total microsurgical resection.…”

Section: Discussionmentioning

confidence: 99%

“…[ 19 ] Nonetheless, when multiple lesions are identified with at least one measuring >4 cm, craniotomy followed by whole-brain radiotherapy treatment yields the best results in terms of overall survival. [ 22 ] Furthermore, preoperative embolization of the choroid plexus may help limit the blood loss and allow total resection. [ 20 ]…”

Section: Discussionmentioning

confidence: 99%

Solitary metastasis from renal cell carcinoma to the choroid plexus: A case illustration and review of the literature

Colamaria

Blagia

Sacco

et al. 2022

Surgical Neurology International

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Background: Metastatic renal cell carcinoma (RCC) of the choroid plexus is an exceedingly rare condition, with only 35 reported cases to date. Surgical resection of these tumors poses a unique challenge to neurosurgeons since evidence-based treatment guidelines are yet to be designed. Case Description: The authors describe the case of a 58-year-old woman presenting with progressive neurological deterioration 5 years after a right nephrectomy for a WHO 2016 Stage I RCC. A head, contrast-enhanced, and magnetic resonance revealed signs of obstructive hydrocephalus and a homogeneously contrast-enhancing 5 cm mass located in the trigone of the right lateral ventricle. Furthermore, a search of the literature was performed in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After screening for duplicates, 35 publications met the eligibility criteria. Finally, 17 manuscripts were included for analysis. Moreover, a detailed description of an illustrative case is provided. The median age at diagnosis for intraventricular metastasis from RCC was 62.9 years, showing a slight female prevalence. The lateral ventricles were reported as the most frequent location with only one patient presenting with obstructive hydrocephalus caused by the obliteration of Monro foramen. Management options included either open craniotomy or radiosurgery. Conclusion: The management of choroid plexus metastasis from RCC is still controversial with various authors proposing different treatment strategies. In this article, in addition to an in-depth case description, a qualitative review of the literature on metastatic RCCs of the choroid plexus using the PRISMA is provided.

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Stereotactic Radiosurgical Treatment of Brain Metastases to the Choroid Plexus

Cited by 18 publications

References 47 publications

The choroid plexus may be an underestimated site of tumor invasion to the brain: an in vitro study using neuroblastoma cell lines

The choroid plexus may be an underestimated site of tumor invasion to the brain: an in vitro study using neuroblastoma cell lines

Choroid Plexus Metastasis of Follicular Thyroid Carcinoma Diagnosed due to Intraventricular Hemorrhage

Solitary metastasis from renal cell carcinoma to the choroid plexus: A case illustration and review of the literature

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