2021
DOI: 10.1088/1758-5090/ac1846
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Stereotactic technology for 3D bioprinting: from the perspective of robot mechanism

Abstract: Three-dimensional (3D) bioprinting has been widely applied in the field of biomedical engineering because of its rapidly individualized fabrication and precisely geometric designability. The emerging demand for bioprinted tissues/organs with bio-inspired anisotropic property is stimulating new bioprinting strategies. Stereotactic bioprinting is regarded as a preferable strategy for this purpose, which can perform bioprinting at the target position from any desired orientation in 3D space. In this work, based o… Show more

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Cited by 11 publications
(5 citation statements)
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“…The bioink was deposited quantitatively and precisely avoiding errors caused by irregular wounds and unexpected motions, which achieved accurate skin repair macroscopically. In conventional three‐axis bioprinting process, the nozzle is constrained in the 2D plane along the direction of gravity, making it inevitable to generate stair‐step effect between neighboring layers, which causes surface distortion of the structure 66 . In addition, curved surface of skin requires the nozzle to adaptively operate in the normal direction according to the specific surface shape, which is insufficient in conventional bioprinter.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The bioink was deposited quantitatively and precisely avoiding errors caused by irregular wounds and unexpected motions, which achieved accurate skin repair macroscopically. In conventional three‐axis bioprinting process, the nozzle is constrained in the 2D plane along the direction of gravity, making it inevitable to generate stair‐step effect between neighboring layers, which causes surface distortion of the structure 66 . In addition, curved surface of skin requires the nozzle to adaptively operate in the normal direction according to the specific surface shape, which is insufficient in conventional bioprinter.…”
Section: Discussionmentioning
confidence: 99%
“…In conventional three‐axis bioprinting process, the nozzle is constrained in the 2D plane along the direction of gravity, making it inevitable to generate stair‐step effect between neighboring layers, which causes surface distortion of the structure. 66 In addition, curved surface of skin requires the nozzle to adaptively operate in the normal direction according to the specific surface shape, which is insufficient in conventional bioprinter. Under the need of fidelity and the anisotropically growing pattern, our series manipulator can perform stereotactic bioprinting due to the extra‐DoF, which allows the print‐head to adjust the printing direction according to the topography of the skin, making it feasible for skin with complex features, such as large inclination or downward surfaces.…”
Section: Discussionmentioning
confidence: 99%
“…Robots have been routinely used in minimally invasive surgical settings[ 28 ], thereby paving the way for in situ bioprinting[ 29 ]. Robot configurations determine the working space, deposition flexibility, and operational precision of bioprinting, of which Cartesian coordinate, articulated, and parallel robots are the main configurations[ 30 ]. The typical robotic-assisted bioprinting process is shown in Figure 2 .…”
Section: In Situ Bioprinting Modalitiesmentioning
confidence: 99%
“…Depending on endpoint TE requirements, either burst or long-term EVs release can be employed for a given TE application. While different bioprinting techniques are widely used in the field, technique choice is also critical to reach a certain scaffold design, for example, microextrusion bioprinting cannot achieve anisotropic properties while stereotactic 3D bioprinting enables deposits of bioinks at a targeted position from any desired orientation (reviewed in [56]). When optimizing bioprinting, the mechanical properties of printed scaffolds with and without EVs should be considered, as hydrogel stiffness, for example, can influence EVs release [57].…”
Section: Bioprinting Optimizationmentioning
confidence: 99%