Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Chong, Josephine; Mulet, Xavier; Boyd, Ben J.; Drummond, Calum J.

doi:10.1016/bs.adplan.2014.11.001

Cited by 85 publications

(78 citation statements)

References 213 publications

(232 reference statements)

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“…39 Moreover, the subsequent hydration of S generated a large repulsive force between the head groups, increasing the distances between the lamellar mesophase until a hexagonal mesophase was formed. [41][42][43] The different geometries of the amphiphilic molecules and their resultant self-assembled structures that were formed in the presence of a solvent can be understood using the critical packing parameter (CPP) concept. 44 CPP is often defined using Equation 3:…”

Section: Ternary-phase Diagrammentioning

confidence: 99%

Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

Fonseca-Santos

Satake

Calixto

et al. 2017

IJN

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Resveratrol (Res) is a common phytoalexin present in a few edible materials, such as grape skin, peanuts, and red wine. Evidence has shown the beneficial effects of Res on human health, which may be attributed to its anti-inflammatory activity. However, the poor aqueous solubility of Res limits its therapeutic effectiveness. Therefore, the use of nanostructured delivery systems for Res, such as liquid-crystalline systems, could be beneficial. In this study, we aimed to develop, characterize, and determine the in vivo effectiveness of Res-loaded liquid-crystalline systems. Systems containing copaiba balsam oil, polyethylene glycol-40 hydrogenated castor oil, and water were designed. Results of polarized light microscopy, small-angle X-ray scattering, texture-profile analysis, and flow-rheology analysis showed that the Res-loaded liquid-crystalline system had a lamellar structure, textural and mechanical (hardness, compressibility, and adhesiveness) properties, and behaved as a non-Newtonian fluid, showing pseudoplastic behavior upon skin application. Furthermore, all liquid-crystalline systems presented bioadhesive properties that may have assisted in maintaining the anti-inflammatory activity of Res, since the topical application of the Res-loaded lamellar mesophase liquid crystals resulted in edema inhibition in a carrageenan-induced paw-inflammation mouse model. Therefore, Res-loaded lamellar mesophases represent a promising new therapeutic approach for inhibition of skin inflammation.

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Section: Ternary-phase Diagrammentioning

confidence: 99%

Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

Fonseca-Santos

Satake

Calixto

et al. 2017

IJN

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“…Phytantriol (PT), which is a well-known cosmetic ingredient [71], is becoming popular in preparing nanostructured particle dispersions [60,[72][73][74]. Some other lipids exploited for the preparation of cubosomes include, monoelaidin, myverol, Soy phosphatidylcholine/glycerol dioleate and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) [74][75][76][77]. Recently we have prepared O/W emulsion using a food material, butter oil, which is a cheap and abundant source of lipid molecules [78].…”

Section: Lipid Nanostructured Emulsions: Next Level Of Structural Hiementioning

confidence: 99%

“…A wide range of stabilizers [76] have been used for O/W emulsions including surfactants [66], silica nanoparticles [79], clay platelets [80] and carbon nanotubes [81,82]. The pluronic F127, a triblock co-polymer has been very popular stabilizer for nanostructured emulsions among others [74,83] ( Figure 5).…”

Section: Lipid Nanostructured Emulsions: Next Level Of Structural Hiementioning

confidence: 99%

Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

Kulkarni

2016

Cosmetics

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A majority of cosmetic products that we encounter on daily basis contain lipid constituents in solubilized or insolubilized forms. Due to their amphiphilic nature, the lipid molecules spontaneously self-assemble into a remarkable range of nanostructures when mixed with water. This review illustrates the formation and finely tunable properties of self-assembled lipid nanostructures and their hierarchically organized derivatives, as well as their relevance to the development of cosmetic formulations. These lipid systems can be modulated into various physical forms suitable for topical administration including fluids, gels, creams, pastes and dehydrated films. Moreover, they are capable of encapsulating hydrophilic, hydrophobic as well as amphiphilic active ingredients owing to their special morphological characters. Nano-hybrid materials with more elegant properties can be designed by combining nanostructured lipid systems with other nanomaterials including a hydrogelator, silica nanoparticles, clays and carbon nanomaterials. The smart materials reviewed here may well be the future of innovative cosmetic applications.

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“…Anticancer (skin and colon cancer) 59 and anti-diabetic activity 60 Low bioavailability (<1%) and unstable in-vivo 61,62 Wild mulberry/ raspberries 4 Nevertheless, the opportunities for enhancing the nutritional values of food by addition of flavonoids are largely unexploited. In particular, the interactions of flavonoids with lipid self-assemblies, formulation of polyphenol-rich mesosomes and eventually engineering of nano structured food supplements with proper taste, stability and digestibility behaviour are scarcely considered.…”

Section: Cyanidinmentioning

confidence: 99%

“…2,3 Within the food and pharmaceutical research, LLC nano materials have shown potentials in the development of novel delivery systems. [4][5][6] These nanostructures are self-assemblies of naturally occurring surfactantlike lipid molecules which are closely related to those observed in biological membranes and empower the formation of efficient delivery matrices due to their impressive characteristics:…”

Section: Introductionmentioning

confidence: 99%

Lyotropic Liquid Crystalline Phases for the Formulation of Future Functional Foods

Sadeghpour¹

2016

JNHFE

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The especial features and advanced characteristics of Lyotropic Liquid Crystalline (LLC) phases as potent nano materials for encapsulation and the development of novel delivery systems for nutraceuticals and other bioactive compounds are reviewed. Exemplary, a focus is set on the health benefits of flavonoids and their current restrictions in bioavailability. Accordingly, our visions for application of LLC phases in the engineering of enhanced flavonoid-based food supplements and correlated challenges to overcome are highlighted.

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Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Cited by 85 publications

References 213 publications

Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

Lyotropic Liquid Crystalline Phases for the Formulation of Future Functional Foods

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