Sterilisation of drug–device combination products

Parsons, Barry J.

doi:10.1533/9781845697488.3.395

Search citation statements

Order By: Relevance

Paper Sections

Select...

Other1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2012

2023

Publication Types

Select...

Article4

Book1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

(1 citation statement)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As can be expected, these demonstrate both the complexity of free radical-induced chemistry and the diversity of protein structure, content and conformation. A review of protein radiation chemistry as it applies to the sterilisation of healthcare products containing proteins and enzymes has also been made by Parsons (2010). It is not the purpose here, therefore, to focus on the radiation chemistry.…”

Section: Sterilisation Of Aqueous Solutions Of Proteins and Enzymes: mentioning

confidence: 99%

Sterilisation of healthcare products by ionising radiation: sterilisation of drug-device products and tissue allografts

Parsons

2012

Sterilisation of Biomaterials and Medical Devices

View full text Add to dashboard Cite

Section: Sterilisation Of Aqueous Solutions Of Proteins and Enzymes: mentioning

confidence: 99%

Sterilisation of healthcare products by ionising radiation: sterilisation of drug-device products and tissue allografts

Parsons

2012

Sterilisation of Biomaterials and Medical Devices

View full text Add to dashboard Cite

Gamma irradiation effect on some asthma drugs: EPR detection of radiosterilization

Emel,

Ayhan,

Recep

et al. 2023

Radiation Protection Dosimetry

View full text Add to dashboard Cite

Among many sterilization methods, radiosterilization is a preferred method in the pharmaceutical industry because of its advantages. However, the detection of radiosterilization of drugs is a growing concern for many government regulatory agencies around the world because of changes in the drug’s structure because of exposure to radiation. Electron Paramagnetic Resonance (EPR) proved to be a very sensitive technique to discriminate between irradiated and nonirradiated drugs and detect radicals for days even to years. In this study, the focus is on the detection of radiosterilization of irradiated three asthma drugs (Airfix, Ventolin and Prednol) by using EPR spectroscopy. Regarding the commercial aspects of drugs, it was found that radicals can be detected at least 2 y after irradiation. Therefore, paramagnetic centers formed by the effect of radiation in the samples were determined and the stability of these centers was examined for 2 y by performing the fading study.

show abstract

Comparative analysis of the effectiveness of modern methods of sterilization of instruments and the place of gas-dynamic treatment with carbon dioxide

Арутюнов¹,

Yanushevich²,

Korsunsky³

et al. 2022

Ross. stomatol.

View full text Add to dashboard Cite

Sterilisation of drug–device combination products

Cited by 5 publications

References 117 publications

Sterilisation of healthcare products by ionising radiation: sterilisation of drug-device products and tissue allografts

Sterilisation of healthcare products by ionising radiation: sterilisation of drug-device products and tissue allografts

Gamma irradiation effect on some asthma drugs: EPR detection of radiosterilization

Comparative analysis of the effectiveness of modern methods of sterilization of instruments and the place of gas-dynamic treatment with carbon dioxide

Contact Info

Product

Resources

About