Sterility and Testicular Atrophy Related to Cyclophosphamide Therapy

Fairley, Kenneth F.; Barrie, Jean U.; Johnson, Warren

doi:10.1097/00006254-197211000-00014

Cited by 18 publications

(23 citation statements)

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“…After long-term CP treatment, it may cause adverse effects such as marked myelosuppression [20], hemorrhagic cystitis [21], gonadal failure [22], and development of malignancies [23]. However, these side effects are usually caused by a cumulative dose of cyclophosphamide.…”

Section: Discussionmentioning

confidence: 99%

Low dose cyclophosphamide rescues myocardial function from ischemia-reperfusion in rats☆

Zhu

Qiu

Wang

et al. 2008

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 99%

Low dose cyclophosphamide rescues myocardial function from ischemia-reperfusion in rats☆

Zhu

Qiu

Wang

et al. 2008

European Journal of Cardio-Thoracic Surgery

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“…34 However, azoospermia in SSNS was reported after administration of a single course of cytotoxic therapy, yet with potential recovery of spermatogenesis after cessation of treatment. 35,36 Female fertility seemed to be less affected by cytotoxic therapy in SSNS. 37,38 A recent meta-analysis recommended a supposedly safe cumulative dosage threshold below 300 mg/kg for a single course of CPO in males.…”

Section: Discussionmentioning

confidence: 99%

Children with Steroid-sensitive Nephrotic Syndrome Come of Age: Long-term Outcome

Rüth

Kemper

Leumann

et al. 2005

The Journal of Pediatrics

151

100

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“…Those who had permanent amenorrhea received approximately 4 g or more cyclophosphamide in addition to the dose given before the onset of amenorrhea. Fairley et al 23 performed serial semen analysis in six patients I week to 6 months after the start of treatment with cyclophosphamide (50-10 mg/day) and found that no patient developed azoospermia unless treatment was given for at least 4 months. At 6 months (cumulative dose 9-I S g) all had germinal aplasia.…”

Section: Discussionmentioning

confidence: 99%

The Long-Term Clinical Outcome of 56 Patients with Biopsy-Proven Lupus Nephritis Followed at a Single Center

Derksen

Hené

Kater

1992

Lupus

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We retrospectively evaluated the clinical outcome of 45 female and 11 male patients with biopsy-proven lupus nephritis, followed at our hospital between February 1974 and February 1990. In the majority signs of nephritis were present at the time systemic lupus erythematosus was diagnosed (range: -42-156 months) and the median time from onset of nephritis to biopsy was 2 months. The median follow-up from the time of the biopsy was 53.5 months (range: 2-192), the median age at biopsy 25 years and the median serum creatinine level 1.2 mg/dl. Initial renal biopsies had the following histopathological classes according to the World Health Organization criteria (n): I (2); II (10); III (10); IV (28); V (5); VI (1). Over the study period active episodes were treated with high-dose oral prednisone alone or combined with intravenous nitrogen mustard and oral chlorambucil (1974-75), azathioprine (1978-86), cyclophosphamide (1986-90) and/or plasma-exchange (1976-84). These strategies were based on literature data or multicenter studies in which we participated. Eight patients developed end-stage renal disease (ESRD) (median: 47 months post-biopsy; range: 20-120). In these, initial biopsies showed class IV in seven, and class V in one. Confounded risk factors for ESRD were class IV biopsy, male gender and serum creatinine level above 1.4 mg/dl. The calculated proportion without ESRD 5 years post-biopsy was 87% (95% confidence limits: 98-76%), and at 10 years 70% (95% confidence limits: 90-49%). Five patients (11.2%) died; causes of death were cerebrovascular accident (n = 2), cerebral lupus (n = 2) and S. aureus sepsis (n = 1).(ABSTRACT TRUNCATED AT 250 WORDS)

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Sterility and Testicular Atrophy Related to Cyclophosphamide Therapy

Cited by 18 publications

References 0 publications

Low dose cyclophosphamide rescues myocardial function from ischemia-reperfusion in rats☆

Low dose cyclophosphamide rescues myocardial function from ischemia-reperfusion in rats☆

Children with Steroid-sensitive Nephrotic Syndrome Come of Age: Long-term Outcome

The Long-Term Clinical Outcome of 56 Patients with Biopsy-Proven Lupus Nephritis Followed at a Single Center

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